Functional genomics scientist Work, Jobs in Amersham, Bkm (with Salaries)

Research Assistant in Brain Vascular Epigenomics – UK Dementia Research Institute
Imperial College London —White City
- £43,863 - £47,223 a year
- Full-time
- C++
- University
- Linux
1d
Functional Genomics Scientist
Substrate Bio —London
- Full-time
- Doctoral degree
- Laboratory experience
- Maintenance
- Annual leave
Quick apply
Molecular Characterisation Scientist, Biologics
Substrate Bio —London
- Full-time
- Doctoral degree
- Laboratory experience
- Master's degree
- Annual leave
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Senior Principal Scientist, Clinical Biomarkers
Ipsen Innovation (SAS) —London
- Full-time
- Doctoral degree
- English
Senior Scientist, Macrophage-stromal biology
Engitix —London
- Doctoral degree
- Master's degree
- IT
Quick apply
Protein Production Scientist, Biologics
Substrate Bio —London
- Full-time
- Doctoral degree
- Master's degree
- Supervising experience
- Annual leave
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Head of Functional Genomics
Substrate Bio —London
- Full-time
- Hybrid work
- Laboratory experience
- AI
- Annual leave
Quick apply
Bioinformatics Scientist
Basecamp Research —London
- Full-time
- Doctoral degree
- Master's degree
- C++
- Life insurance
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Senior Research Scientist, Mathematical Foundations
Basecamp Research —London
- Full-time
- Machine learning
- Life insurance
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Senior Bioinformatics Scientist
Basecamp Research —London
- Full-time
- Doctoral degree
- Master's degree
- Bachelor's degree
- Life insurance
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Chemistry Principal Scientist
Substrate Bio —London
- Full-time
- Hybrid work
- Doctoral degree
- AI
- Annual leave
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Senior Data Scientist - (Privacy & Security Controls)
Our Future Health —London
- From £80,000 a year
- Full-time
- Hybrid work
- Machine learning
- Communication skills
- Python
- Employee assistance programme
- Referral programme
Quick apply
Technical Talent Lead
Basecamp Research —London
- Full-time
- Life insurance
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Senior Research Engineer, ML Systems
Basecamp Research —London
- Full-time
- Doctoral degree
- Computer Science
- Maths
- Life insurance
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Associate Director, Data Science
Bristol-Myers Squibb —Uxbridge
- Full-time
- Hybrid work
- Azure
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- Doctoral degree
Senior Manager, Data Sciences
Bristol-Myers Squibb —Uxbridge
- Full-time
- Hybrid work
- Azure
- Doctoral degree
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Sales Director, Europe
Plasmidsaurus —London
- Full-time
- Communication skills
AI Engineering Lead
Substrate Bio —London
- Full-time
- Hybrid work
- Doctoral degree
- Master's degree
- APIs
- Annual leave
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VP, Business Development
Substrate Bio —London
- Full-time
- Hybrid work
- Laboratory experience
- Business development
- Bachelor's degree
- Annual leave
Quick apply
Community Manager
Substrate Bio —London
- Full-time
- Hybrid work
- Bachelor's degree
- APIs
- IT
- Annual leave
Quick apply

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Research Assistant in Brain Vascular Epigenomics – UK Dementia Research Institute

Imperial College London -
White City

Apply Now

Job details

Full-time
£43,863 - £47,223 a year
1 day ago

Benefits

Company pension

Qualifications

Dementia care
MATLAB
R
UNIX
Git
C++
GitHub
Linux
Python

Full job description

Job number

MED05913

Faculties

Faculty of Medicine

Departments

Department of Brain Sciences

Salary or Salary range

£43,863 - £47,223 per annum

Location/campus

White City Campus - On site only

Contract type work pattern

Full time - Fixed term

Posting End Date

17 Aug 2026

About the role

Launched in 2017, the UK Dementia Research Institute stands as a beacon of scientific innovation, representing an unprecedented £300 million investment in dementia research — the largest of its kind in UK history. The purpose of the UK DRI is to transform the outlook for people living with or at risk of neurodegenerative conditions through research.

We are inviting applications for a Research Assistant in computational brain vascular epigenomics, funded by the Uren Foundation, to join the laboratory of Dr Alexi Nott (https://nottgroup.com/index.html) in the UK DRI at Imperial College London.

Vascular dysfunction is one of the earliest pathological features of dementia, preceding clinical onset and representing a critical but underexplored window for therapeutic intervention. Our recent work has demonstrated that the brain neurovascular unit is a key driver of genetic risk for small vessel disease, and that epigenomic profiling of vascular cell types can be used to prioritise repurposable drug targets for dementia (Ziegler et al., Neuron, 2026). The successful candidate will contribute to a translational research project investigating cell-type-specific gene regulatory mechanisms underlying small vessel disease, with the aim of identifying targets of vascular dysfunction relevant to dementia. This work carries direct translational potential, with the opportunity to contribute to the prioritisation of both repurposable and novel therapeutic candidates underpinned by human epigenetic and genetic evidence.

This is an excellent opportunity for a motivated individual with an interest in computational biology to gain experience at the forefront of dementia research. The Nott group is multidisciplinary, and the post holder will work closely with both computational scientists and experimentalists, gaining broad exposure to cutting-edge epigenomic approaches and translational neuroscience.

What you would be doing

Using your experience in (epi)genomics of the brain, you will:

Lead the analysis of analyse large-scale epigenomic and multi-omics datasets from human vascular and immune cell types.
Develop and maintain bioinformatic pipelines and analytical workflows, applying rigorous standards to ensure robust and reproducible results.
Contribute to the functional interpretation of noncoding disease risk variants linked to vascular dysfunction, guiding the identification of genetically supported therapeutic targets.
Work collaboratively as part of a multidisciplinary research team, including computational scientists and experimentalists, within the UK DRI and with external collaborators.

What we are looking for

We are seeking a motivated and organised researchers who is excited by the science we do! You will have:

Strong programming skills in R, Python, or other coding languages (e.g. C++, Matlab), with knowledge of Unix/Linux environments and version control systems such as Git and GitHub.
Experience working with large-scale genomic datasets, ideally CUT&Tag, and/or ATAC-seq, ChIP-seq, single-cell/nucleus genomics, RNA-seq.
Experience with high-performance computing environments and the development of bioinformatic workflows using tools such as Nextflow.
Knowledge of chromatin biology, gene regulation, and/or vascular and immune cell types, ideally in the context of the brain, is highly desirable.
Experience working with GWAS summary statistics and/or population genetic analyses would be advantageous.

What we can offer you

This role is part of the UK Dementia Research Institute (UK DRI) at Imperial College London, located in the Department of Brain Sciences. Researchers in the UK DRI at Imperial enjoy excellent career development opportunities with:

Access to a range of cutting-edge technologies.
An inclusive and collegial working environment with the opportunity to mentor, supervise and teach students.
Strong national links through the UK DRI and attendance at relevant scientific meetings.

The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
Grow your career: gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression.

Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes).

Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing.

Further information

This is a full time fixed term role, based at our White City Campus.

If you require any further details about the role, please contact: Dr Alexi Nott [email protected]

Available documents

Attached documents are available under links. Clicking a document link will initialize its download.

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.

We reserve the right to close the advert prior to the closing date stated, should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.

If you encounter any technical issues while applying online, please don't hesitate to email us at [email protected]. We're here to help.

About Imperial

Welcome to Imperial, a global top-ten university where scientific imagination leads to world-changing impact.

Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world’s toughest challenges. Whatever your role, your contribution will have a lasting impact.

As a member of our vibrant community of 22,000 students and 8,000 staff, you’ll collaborate with passionate minds across nine London campuses and a global network.

This is your chance to help shape the future. We hope you’ll join us at Imperial College London.

Our Culture

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our web pages.

Proud signatory of the Armed Forces Covenant. We welcome applications from the Armed Forces community.

Our values are at the root of everything we do, and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.

Apply Now

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functional genomics scientist jobs in amersham, bkm

Research Assistant in Brain Vascular Epigenomics – UK Dementia Research Institute