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Postdoctoral Research Associate in Structural Biology
University of Oxford —Oxford
- £39,424 - £47,779 a year
- Doctoral degree
- School
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Postdoctoral Research Associate in Structural Biology

University of Oxford -
Oxford

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Job details

Fixed term contract
£39,424 - £47,779 a year

Qualifications

Doctoral degree

Full job description

We are seeking an ambitious Postdoctoral Research Associate to join the laboratory of Dr Georgia Isom at the Sir William Dunn School of Pathology, University of Oxford, to uncover the molecular machinery that transports sphingolipids to the surface of Gram-negative bacteria. This exciting project combines cryo-electron microscopy, native mass spectrometry, proteomics, and bacterial cell biology to answer a fundamental question in bacterial membrane biology.

For decades, sphingolipids were thought to be almost exclusively eukaryotic membrane components, with only a handful of unusual bacteria capable of producing them. Our recent discoveries have overturned this view, revealing that sphingolipid biosynthesis is widespread across diverse bacteria. Emerging evidence suggests sphingolipids are key determinants of membrane homeostasis, environmental adaptation, antimicrobial resistance and host-pathogen interactions. Yet one of the biggest questions in the field remains unanswered: how are sphingolipids transported across the bacterial cell envelope to reach the cell surface?

As the successful candidate, you will drive this project by combining structural and mechanistic approaches to identify and characterise sphingolipid transport systems. You will determine high resolution single particle cryo-EM structures of sphingolipid transporters. In parallel, you will assess sphingolipid-transporter interactions and the role of the sphingolipids in membrane homeostasis using a combination of mass spectrometry and cellular electron microscopy methods.

The post-holder should hold, or be close to completion of, a PhD in structural biology and have experience of solving high resolution structures using single particle cryo-EM. You should be highly motivated, organised and able to work independently as well as part of a team.

This is a fixed-term appointment available for 2 years in the first instance (with funds to extend) with the position available from autumn/winter 2026. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. Informal enquiries could be sent to Dr Georgia Isom via email: [[email protected]](mail to:[email protected]).

Only applications submitted online and received before noon Friday 31st July 2026 will be considered. Interviews will be held soon thereafter.

At the Dunn School we are committed to supporting the professional and career development of our postdocs and research staff. To help them thrive and achieve their ambitions, we have created a comprehensive range of opportunities and initiatives designed to provide an exceptional launchpad for their future careers.

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