Overview
We are seeking an independent and motivated Research Associate to work on an MRC-funded project focusing on the links between metabolism and epigenetic regulation of stem cell fate decisions. The successful applicant will employ genetically engineered human pluripotent stem cell (hPSC) lines to examine how one-carbon metabolism, a key biochemical pathway generating essential metabolites for epigenetic regulation, influences neural differentiation. This project is a close collaboration with the group of Dr Yaser Atlasi from Queen's University Belfast.
Applicants must hold a PhD (or be close to completion / have equivalent postdoctoral work experience) in a subject related to stem cell/developmental biology. Experience in culture and differentiation of hPSCs toward neuronal lineages alongside immunocytochemistry/imaging, flow cytometry and qPCR are essential. The successful candidate will be expected to have excellent interpersonal, written and communication skills, and be able to work to a high standard.
Main duties and responsibilities
- Conduct personal research of international standing into the above-mentioned remit for the study. Moreover, the postholder needs to be able to identify literature and updating own knowledge, assessing the validity of the relevant literature and its contribution to the development of own field.
- Determine novel research objectives as experiments progress and initiate and implement relevant programme of research.
- Disseminate research findings/results through the production of papers for high quality journals and presentation either in-house or at national/international conferences or seminars.
- Efficiently manage time, materials, finance and equipment.
- Provide support to PI for research proposals and funding applications.
- Supervise or co-supervise undergraduate/postgraduate project students and/or PhD students.
- Delegate and monitor the work of research students.
- Deal with reactive requests relating to supervision of research staff and students.
- Participate in consortium meetings and seminars, in particular with collaborators
- Plan up to several months in advance to meet deadlines for journal publications and to prepare presentations and papers for collaboration meetings and conferences.
- As a member of staff you will be encouraged to make ethical decisions in your role, embedding the University sustainability strategy into your working activities wherever
- Carry out other duties, commensurate with the grade and remit of the post
Person Specification
Our diverse community of staff and students recognises the unique abilities, backgrounds, and beliefs of all. We foster a culture where everyone feels they belong and is respected. Even if your past experience doesn't match perfectly with this role's criteria, your contribution is valuable, and we encourage you to apply. Please ensure that you reference the application criteria in the application statement when you apply.
A PhD (or be close to completion / have equivalent postdoctoral work experience) in an area related to stem cell/developmental biology
Experience with culture and differentiation of human pluripotent stem cells (hPSCs) toward neuronal lineages
Experience in qPCR, flow cytometry and immunocytochemistry/imaging techniques
Effective communication skills, both written and verbal, report writing skills, experience of delivering presentations
Experience of working as part of a collaborative team and a willingness to supervise PhD and undergraduate students
Excellent record keeping and data management skills, with appropriate IT experience
Ability to analyse and solve problems with an appreciation of longer-term implications
Ability to assess and organise resources, and plan and progress work activities
Ability to keep up to date with ongoing research associated with current projects
Ability to work flexibly according to the biological demands of the experimental system and availability of equipment
Further Information
£38,784 - £42,254 per annum
Fixed-term for 12 months from 1 March 2027 to 28 February 2028
Senior Lecturer (Principal investigator)
If you do not currently hold the right to work in the UK, you can find more information here to help determine your visa eligibility. Additional guidance is also available on the UK Visa & Immigration website.
School of Biosciences and Tsakiridis Lab
For informal enquiries about this job contact: Anestis Tsakiridis (Senior Lecturer / Principal investigator) at
[email protected] Next steps in the recruitment process
It is anticipated that the selection process will take place in the weeks after the closing date. following interview of shortlisted candidates. This will consist of a short research presentation and an interview. We plan to let candidates know if they have progressed to the selection stage within two weeks of the closing date. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact
[email protected].
Our vision and strategic plan
We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision ().
What we offer
- A minimum of 41 days annual leave including bank holiday and closure days (pro rata) with the ability to purchase more.
- Flexible working opportunities, including hybrid working for some roles.
- Generous pension scheme.
- A wide range of discounts and rewards on shopping, eating out and travel.
- A variety of staff networks, providing opportunities for social interaction, peer support and personal development (for example, Race Equality, LGBT+, Women’s and Parent’s networks).
- Recognition Awards to reward staff who go above and beyond in their role.
- A commitment to your development access to learning and mentoring schemes
- A range of generous family-friendly policies
- paid time off for parenting and caring emergencies
- access to menopause support in the workplace
- paid time off and support for fertility treatment
- and more
We are a Disability Confident Leader (opens in a new window). If you have a disability and meet the essential criteria for this job you will be invited to take part in the next stage of the selection process.
