The Senior Director, Head of Trial Optimization & Feasibility (TOF), is a strategic enterprise leader accountable for defining and governing the sponsor‑side feasibility, enrollment forecasting, and protocol optimization model across a global, highly outsourced clinical development organization. This role provides authoritative guidance, sets the strategic direction for feasibility excellence, and ensures all enrollment, country, and site assumptions are evidence‑driven, risk‑adjusted, and operationally sound before advancing to governance.
As the organization’s central decision maker on feasibility integrity, this leader influences functions across R&D - Clinical Operations, Clinical Development, Medical Affairs, Analytics, and Vendor Alliance teams, driving alignment on strategic enrollment strategies and challenging assumptions with confidence and rigor. The Head of TOF builds and leads a high‑performing analytics function, elevates modeling sophistication, and embeds standardized frameworks that improve forecast accuracy and strengthen portfolio performance.
Operating as a trusted advisor to senior leadership, this role shapes enterprise standards, anticipates and mitigates operational risk, and ensures feasibility is treated as a strategic differentiator. Through strategic insight, operational leadership, and strong cross‑functional influence, the Head of TOF accelerates decision‑making, improves predictability, and drives accountability, transparency, and continuous improvement across the global development portfolio. This role will also own and contribute elements of Sustainability including, but not limited to, DCT, Patient Surveys and Data, Tokenization, DHT, TA level patient burden assessment, Diversity.
