The purpose of this role is to support the introduction, optimisation and delivery of new processes within the CGT Catapult Manufacturing Innovation Centres (MICs). The MS&T (Manufacturing Science and Technology) Scientist contribute to new product introduction, technology transfer, and GMP manufacturing across Cell Therapy and Viral Gene Therapy processes and aligned modalities.
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Provide technical expertise in a recognised modality, with a broad understanding of aligned technologies
- Apply in-depth knowledge of process engineering, aseptic handling, molecular biology, biochemistry and/or purification techniques to evaluate and optimise cell and gene therapy methodologies to support technology transfer of robust and scalable manufacturing processes
- Execute hands-on developmental or scale-up runs associated with the establishment of new processes within CGT Catapult
- Support the creation and execution of technology transfer project plans for the introduction of new processes to the CGT Catapult MICs in Stevenage and Braintree
- Collaborate with Scale Enabling Technology (SET), Quality, and project teams across the CGT Catapult
- Facilitate collaboration with therapy/technology developers, CMOs and CROs, both at the CGT Catapult MICs and by offsite working
- Ensure documentation compliance with onsite QMS and HSE
- Author and review new GMP procedures and batch related documentation for the CGT Catapult MICs
- Produce project reports and present progress against project deliverables
- Deputise for the MS&T Senior Scientist(s) as required, representing CGT Catapult in technical collaborations
Experience:
- Demonstrable academic or industrial experience in a process development and/or GMP manufacturing setting (essential)
- Demonstrable experience in two or more cell and gene based therapy methodologies e.g. mammalian/primary cell culture, single-use stirred tank reactor (STR) operation, chromatography, tangential flow filtration (TFF) and/or normal flow filtration, continuous centrifugation, aseptic handling including tube welding and sealing etc. (essential)
- Demonstrable experience of working within either the biotech, biopharma, CMO, CRO or other types of commercial-facing organisations (desirable)
- Demonstrable experience of the Quality by Design (QbD) approach to product development (desirable)
- Demonstrable experience of working to commercial timelines and within budget (desirable)
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Highly motivated, pragmatic, and practical to support the mission of the Cell and Gene Therapy Catapult to accelerate the development of a commercial cell and gene-based therapy industry in the UK
- Desire to establish a high-profile career within cell and gene sector and the personal drive to help push the sector to be a commercial success
- Proven knowledge of cutting-edge solutions to address challenges of scalability, and enclosed disposable systems
- Excellent interpersonal, verbal and written communication skills (including presentation skills)
- Ability to quickly establish credibility and build rapport and trust
- Proven ability to engage constructively with colleagues at all levels across different departments to deliver objectives and to respond to a wide range of Collaborator and management needs
- Ambitious, collaborative, driven
- A good team player with a hands-on approach, and adaptable to new challenges
- Flexible and pragmatic, able to learn quickly and respond flexibly to project needs and priorities
- Flexibility towards work assignments and new learning
- Resilient, with the ability to manage multiple and varied tasks and prioritise workload within a fast-paced professional environment, with a strong attention to detail
- A “roll your sleeves up” hands-on attitude towards varying work assignments
- Comfortable operating autonomously once goals and objectives are set
- Ability to work well under pressure and to be able to take the initiative when completing tasks to deliver objectives and to respond to a wide range of Collaborator and management needs
- Proficient in Microsoft 365 applications, with strong IT, data management and presentation skills
- A positive attitude towards learning, personal and professional development
- Keeps up to date with professional knowledge, expertise and best practice
- Willingness to travel as required by the role
Education / Qualifications:
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Educated to a degree level within a Life Science subject
Cell and Gene Therapy Catapult (CGT Catapult) is an independent innovation and technology organisation committed to the advancement of the cell and gene therapy industry. CGT Catapult’s vision for the UK Industry is: globally-leading companies delivering transformative medicine to the world. Its mission is to create a pathway to accelerate breakthrough research in advanced therapies to commercialisation and scale. CGT Catapult works with Innovate UK. For more information, please visit https://ct.catapult.org.uk/ or https://www.ukri.org/councils/innovate-uk/.
CGT Catapult is committed to providing an equal, diverse, and inclusive work environment where everyone’s contributions are valued. We celebrate differences, empower, and inspire everyone, because when everyone is included, everyone wins. In 2024, we received bronze accreditation from Inclusive Employers.
