About Metrion
Metrion Biosciences ('Metrion') is a UK-based, ion channel-focused Contract Research Organisation (CRO) providing high-quality in vitro preclinical drug discovery and safety profiling services. From our headquarters at Granta Park, Cambridge, we support a global customer base with ion channel drug discovery screening, cardiac safety profiling, and neuroscience assay services.
Role Summary
We are seeking a motivated Electrophysiology Scientist / Senior Scientist to join our Ion Channel Screening team on a 12-month fixed-term contract. The successful candidate will support the delivery of high-quality ion channel screening studies using plate-based and automated electrophysiology platforms across a range of client drug discovery programmes.
The role involves performing ion channel screening studies, analysing data and working collaboratively with multidisciplinary project teams to deliver high-quality data for client programmes. Experience in cardiac electrophysiology, including the use of stem cell-derived cardiomyocytes, would be advantageous.
Key Responsibilities
- Perform plate-based ion channel screening assays to support client drug discovery programmes.
- Conduct experiments using automated electrophysiology platforms to generate high-quality pharmacological data.
- Perform electrophysiology studies using recombinant cell lines and stem cell-derived cardiomyocytes.
- Prepare cells, solutions and test compounds for electrophysiology experiments.
- Analyse electrophysiological data using established analysis workflows and prepare data summaries and reports.
- Work closely with project teams to ensure the timely delivery of client studies.
- Maintain accurate laboratory records and work in accordance with company quality systems and standard operating procedures.
- Assist with the maintenance, calibration and routine operation of electrophysiology instrumentation.
- Contribute to the continuous improvement of screening assays, laboratory workflows and scientific capability.
Essential Skills and Qualifications
- MSc, PhD or equivalent experience in physiology, pharmacology, neuroscience or a related biological science.
- Practical experience in whole-cell patch-clamp electrophysiology.
- Experience with electrophysiology data analysis.
- Strong attention to detail and the ability to generate high-quality, reproducible data.
- Excellent organisational, written and verbal communication skills.
- Ability to work independently and collaboratively within a multidisciplinary scientific team.
- A proactive, flexible approach and enthusiasm for delivering high-quality science.
Desirable Skills and Experience
- Experience with automated electrophysiology platforms.
- Experience in plate-based ion channel screening assays.
- Experience working with stem cell-derived cardiomyocytes (hiPSC-CMs).
- Background in cardiac electrophysiology and/or cardiac ion channel pharmacology.
- Industrial or CRO experience.
Why Metrion?
At Metrion, you will:
- Join a leading UK CRO specialising in ion channel drug discovery and safety pharmacology.
- Work with state-of-the-art automated electrophysiology platforms and cutting-edge cardiac models.
- Contribute to innovative drug discovery programmes spanning ion channels, cardiac safety and neuroscience.
- Be part of a collaborative, supportive and scientifically driven team.
- Receive a competitive salary and comprehensive employee benefits package.
Interested applicants should send a CV and cover letter summarising their interest and suitability for the role to [email protected].
Pay: £30,000.00-£40,000.00 per year
Benefits:
- Company pension
- Free parking
- Life insurance
- On-site parking
- Private medical insurance
- Sick pay
Application question(s):
- Do you have practical experience with electrophysiology
Education:
Work authorisation:
- United Kingdom (required)
Work Location: In person
