About Sygnature Discovery
At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.
We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.
Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 250 patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.
About the role:
Our Protein Science team specialises in the engineering, expression and purification of tailored proteins across a wide range of protein classes for applications including biochemical screening, biophysics, diagnostics and biologics drug discovery. We also have a dedicated team of scientists carrying out structural studies using X-ray crystallography, Cryo-EM and protein NMR, giving you the opportunity to work alongside experts across multiple disciplines using cutting-edge technologies.
Due to continued growth, we're looking for Scientists and Senior Scientists to join our Protein Science team at our Tytherington site in Macclesfield. We're looking for curious and passionate scientists with hands-on experience in either protein expression, purification and structural determination. Experience in protein engineering and biophysical or structural characterisation techniques would be an advantage.
As a global CRO, you'll have the opportunity to work across a diverse portfolio of client projects rather than focusing on a single programme. You'll collaborate with talented scientists from across the business, tackle a broad range of scientific challenges and help our clients accelerate the discovery of tomorrow's medicines.
If you're looking for variety, enjoy solving complex scientific problems and want to be part of a collaborative, innovative team, we'd love to hear from you!
Role Responsibilities:
Protein Expression involving the expression of recombinant proteins in bacterial, insect and mammalian systems
Protein purification and analysis of a broad range of targets including membrane proteins
Structural Biology – X-ray crystallography, biomolecular NMR and CryoEM
Skills & Qualifications:
As a minimum you will have a BSc/MSc or PhD in Biochemistry or a related discipline
Drugs discovery experience in a CRO is advantageous however not essential
Successful project delivery will be achieved through your own individual experimental work and by working flexibly with colleagues.
Excellent problem-solving skills and in some of the techniques involved in protein expression, purification and analysis including structural biology.
Strong interpersonal and communications skills and a natural broader curiosity
Benefits
25 days annual leave (plus bank holidays)
Private Medical Insurance
️ Life Insurance
Employee Assistance Programme
️ Enhanced Family Friendly Policies
Sygnature Group Pension Scheme
1 paid volunteer day per year
Please note: This advert may close early if we receive a high volume of applications. We encourage you to submit your application as soon as possible to avoid missing out on this opportunity.
