Director, Project Toxicologist – – Immune Oncology (IO) Safety Science
Location: Cambridge, UK (Hybrid, required 60% presence in the office)
Salary: Competitive
At AstraZeneca, our bold ambition is nothing less than to eliminate cancer as a cause of death. Our pioneering pipeline of oncology medicines reflects this mission, and our Immune Oncology (IO) Safety team plays a critical role in accelerating transformative therapies to patients.
We are seeking a highly motivated, innovative, and passionate Director, Project Toxicologist, to join our IO Safety group. This role focuses on novel immunotherapeutic, including immune cell engagers. Candidates with a strong Immunology and toxicology background, preferably in Oncology, are encouraged to apply.
You will partner with cross-functional teams across Oncology R&D, bridging discovery and regulatory toxicology, Immunotoxicology, driving innovative safety strategies, and accelerating drug development. Your expertise will inform candidate selection, guide regulatory strategy, and help define the future of oncology safety science.
What You’ll Do
As a core member of multi-disciplinary drug development teams, you will deliver globally acceptable toxicological packages to predict, assess and mitigate target and modality related safety risks to support data-driven decisions across discovery and development programs.
You will develop and implement innovative solutions to combine regulatory toxicology with ground breaking science and technologies to progress novel drug candidates to the clinic and through development to the market, in line with business needs.
Influence project strategy and decision making, communicate clear positions on integrated risk assessments in various formats including informing internal decision-making governance bodies and interacting with external health authorities.
Deliver quality non-clinical summaries and contribute to regulatory submissions for IO projects.
Maintain and expand expertise in regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.
Education/Experience Requirements
DABT or PhD in toxicology or immunology (or equivalent) with several years of experience in the pharmaceutical or biotechnology industry working as a non-clinical safety lead, supporting immunology and/or oncology programs with planning, execution, interpretation and communication of regulatory toxicology data.
A proven understanding of drug discovery and development, with a track record of delivering multiple toxicology programs supporting IND/CTA filings.
High level of knowledge and expertise in designing toxicology strategies and delivering in vitro/in vivo and risk assessment of immune/target related risks, driven by the pharmacology of IO therapeutics.
Ability to solve problems in a goal-focused fashion with willingness to challenge conventional thinking and capacity to coordinate tasks across multiple projects and geographies.
Excellent verbal and written communication, interpersonal- and influencing skills. Adopting an inclusive and collegiate working style, and a desire to drive own- and support others development. Represent AstraZeneca interests, maintaining high ethical and scientific standards.
Commitment to inclusion and diversity, supporting AstraZeneca’s Great Place to Work objectives.
So, what’s next?
Complete your application before the below closing date 8th September 2026
Where can I find out more?
Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
If you are ready to make a meaningful difference in cancer treatment, we want you on our team.
Apply today and help us transform the future of oncology!
Date Posted
24-Aug-2026
Closing Date
06-Sept-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
