Associate scientist Work, Jobs in Datchet, Brk (with Salaries)

Research Associate in Brain Vascular Epigenomics – UK Dementia Research Institute
Imperial College London —White City
- £50,733 - £59,484 a year
- Full-time
- Doctoral degree
- Research
- University
Senior Pharmacovigilance (PV) Scientist
Biogen —Maidenhead
- Full-time
- Hybrid work
- Microsoft Powerpoint
- Microsoft Word
- Doctoral degree
Research associate in Vascular Pharmacology
Imperial College London —Hammersmith
- £45,399 - £52,675 a year
- Full-time
- Doctoral degree
- Laboratory experience
- Research
4d
Research Fellow in Brain Vascular Biology and Brain Cancer Biology
University College London —London
- £43,374 - £51,860 a year
- Full-time
- Doctoral degree
- English
- Research
- Annual leave
- Employee assistance programme
Translational Medicine Expert – Dermatology, Associate Director
Novartis —London
- £67,900 - £126,100 a year
- Full-time
- Hybrid work
- Doctoral degree
- English
- Business development

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Research Associate in Brain Vascular Epigenomics – UK Dementia Research Institute

Imperial College London -
White City

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Job details

Full-time
£50,733 - £59,484 a year

Benefits

Company pension

Qualifications

Doctoral degree
Research
Multidisciplinary collaboration
Bioinformatics

Full job description

Job number

MED05914

Faculties

Faculty of Medicine

Departments

Department of Brain Sciences

Salary or Salary range

£50,733 - £59,484 per annum

Location/campus

White City Campus - On site only

Contract type work pattern

Full time - Fixed term

Posting End Date

23 Aug 2026

About the role

Launched in 2017, the UK DRI stands as a beacon of scientific innovation, representing an unprecedented £300 million investment in dementia research - the largest of its kind in UK history. The purpose of the UK DRI is to transform the outlook for people living with or at risk of neurodegenerative conditions through research.

Applications are invited for a postdoctoral Research Associate in brain vascular epigenomics, funded by the Michael Uren Foundation, to join the laboratory of Dr Alexi Nott (https://nottgroup.com/index.html) in the UK DRI at Imperial College London.

Vascular dysfunction is one of the earliest pathological features of dementia, preceding clinical onset and representing a critical but underexplored window for therapeutic intervention. Our recent work has demonstrated that the brain neurovascular unit is a key driver of genetic risk for small vessel disease, and that epigenomic profiling of vascular cell types can be used to prioritise repurposable drug targets for dementia (Ziegler et al., Neuron, 2026). Building on these findings, the post holder will lead a translational research project investigating the cell-type-specific gene regulatory mechanisms underlying small vessel disease, with the aim of identifying and validating targets of vascular dysfunction relevant to dementia. This work carries direct translational potential, with the opportunity to contribute to the prioritisation of both repurposable and novel therapeutic candidates underpinned by human epigenetic and genetic evidence.

What you would be doing

Using your experience in (epi)genomics of the brain, you will:

Generate and analyse large-scale epigenomic and multi-omics datasets from human vascular and immune cell types isolated from post-mortem brain tissue, to identify signalling pathways and transcription factors dysregulated in small vessel disease and dementia.
Contribute to the functional interpretation of noncoding disease risk variants linked to vascular dysfunction, guiding the identification of genetically supported therapeutic targets.
Work collaboratively as part of a multidisciplinary research team, including computational scientists and experimentalists, within the UK DRI and with external collaborators.

What we are looking for

We are seeking a motivated and organised researchers who is excited by the science we do! You will have:

Demonstrable hands-on experience in (epi)genomics techniques such as CUT&Tag, ChIP-seq, or ATAC-seq, ideally in the brain.
A strong foundational understanding of neuroscience, or a closely related discipline, with knowledge of gene regulatory mechanisms and an appreciation of how epigenomics can be used to interpret genetic variation.
Experience with nuclei isolation and/or fluorescence-activated nuclei sorting (FANS) or FACS, preferably from brain or human tissue.
Experience with R or Python and familiarity with bioinformatics pipelines would be advantageous but is not essential.

What we can offer you

This role is part of the UK Dementia Research Institute (UK DRI) at Imperial College London, located in the Department of Brain Sciences. Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:

Access to a range of cutting-edge technologies.
An inclusive and collegial working environment with the opportunity to mentor, supervise and teach students.
Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.

The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
Grow your career: gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression.

Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes).

Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing.

Further information

This is a Full time, fixed term role based at our White City Campus.

If you require any further details about the role, please contact: Dr Alexi Nott [email protected]

Available documents

Attached documents are available under links. Clicking a document link will initialize its download.

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.

We reserve the right to close the advert before the stated closing date, should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.

If you encounter any technical issues while applying online, please don't hesitate to email us at [email protected]. We're here to help.

About Imperial

Welcome to Imperial, a global top-ten university where scientific imagination leads to world-changing impact.

Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world’s toughest challenges. Whatever your role, your contribution will have a lasting impact.

As a member of our vibrant community of 22,000 students and 8,000 staff, you’ll collaborate with passionate minds across nine London campuses and a global network.

This is your chance to help shape the future. We hope you’ll join us at Imperial College London.

Our Culture

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our web pages.

Proud signatory of the Armed Forces Covenant. We welcome applications from the Armed Forces community.

Our values are at the root of everything we do, and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.

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associate scientist jobs in datchet, brk

Research Associate in Brain Vascular Epigenomics – UK Dementia Research Institute

Senior Pharmacovigilance (PV) Scientist

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