Senior principal scientist Work, Jobs in London Se1 (with Salaries)

Senior Principal Scientist / Director – Computational Chemistry (IDD)
Pharmaron —Hoddesdon
- Doctoral degree
- AI
- Leadership
Quick apply
Principal Data Scientist
CoMind —London
- £152,000 - £190,000 a year
- Full-time
- IT
- AI
- Leadership
- Employee discount
10d
MRI Principal Clinical Scientist
University College London Hospitals NHS Foundation Trust —London
- £75,328 - £86,114 a year
- Full-time
- University
- Leadership
Senior/Principal Project Manager - Renewables
AECOM —London
- Full-time
- Hybrid work
- Engineering
- Bachelor's degree
Senior/Principal Platform Engineer
Paebbl —London
- £90,000 - £110,000 a year
- Hybrid work
- AWS
- Computer networking
- Python
- Annual leave
Senior Technologist - CTP London Threat Mitigation Technologies
Metropolitan Police —Southwark
- £68,112 - £72,953 a year
- Full-time
- Hybrid work
- Engineering
- Annual leave
2d
Senior Principal AI Engineer
Expleo —London
- Azure
- AWS
- AI
Senior/Principal Wind Energy Yield Analyst
AECOM —London
- Full-time
- Hybrid work
- Engineering
- Data analysis skills
- Master's degree
Senior / Principal Civil 3D Modeller
AECOM —London
- Full-time
- Hybrid work
- AutoCAD
- Civil engineering
- Engineering
Senior Principal AI Engineer
Synapri —London
- £90,000 - £120,000 a year
- Hybrid work
- Azure
- AWS
- Presentation skills
Chemistry Principal Scientist
Substrate Bio —London
- Full-time
- Hybrid work
- Doctoral degree
- AI
- Annual leave
Quick apply
Principal Data Scientist I
RELX —London
- Full-time
- Machine learning
Principal Product Manager
Gigaton —London
- £100,000 - £130,000 a year
- Full-time
- Hybrid work
- Travel
- AI
Quick apply
Principal Data Scientist I
RELX Group —London
- Full-time
- Machine learning
Assistant Technologies Manager, Sequencing Scientist and Deputy Institute Safety Officer
University College London —London
- £43,981 - £52,586 a year
- Full-time
- University
- Annual leave
- Employee assistance programme
12d
Principal Data Scientist I
LexisNexis Risk Solutions —London
- Full-time
- Machine learning
Director, Preclinical External Innovation
Life Arc —London
- Full-time
- Doctoral degree
- Leadership
- Communication skills
- Annual leave
9d
Senior/Principal Hydrogeologist
AECOM —Croydon
- Full-time
- Hybrid work
- Master's degree
- Bachelor's degree
Principal Data Scientist
Lendable —London
- Full-time
- Hybrid work
- Management
- SQL
- Machine learning
- Referral programme
Director, Preclinical External Innovation
LifeArc —London
- Full-time
- Doctoral degree
- Leadership
- Communication skills
- Annual leave
9d

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Senior Principal Scientist / Director – Computational Chemistry (IDD)

Pharmaron -
Hoddesdon

Quick apply

Job details

Qualifications

Doctoral degree
AI
Leadership
Communication skills

Full job description

Job Introduction

Senior Principal Scientist / Director – Computational Chemistry (IDD)

Location: UK - Remote

Pharmaron is looking for a Senior Principal Scientist / Director – Computational Chemistry to lead on the design and optimisation of multi-modality ligands within our Integrated Drug Discovery programmes and help shape our Computational Sciences capability.

This is a senior role requiring scientific excellence, and client engagement to drive integrated, multi-modality drug discovery programmes.

The Integrated Drug Discovery (IDD) Services group at Pharmaron is responsible for leading and delivering drug discovery projects for our client partners. The team comprises scientific expertise and strategic leadership across medicinal chemistry, CADD, biology, DMPK and translational science. Combined with Pharmaron’s global research capabilities, we design and deliver integrated programmes from target identification and hit finding, through to IND filing. Working closely with our partners, we define strategy, coordinate execution across teams and, with an AI enabled accelerated Design–Make–Test–Analyse cycle, support the progression of projects and innovative medicines towards the clinic.

The Role

Lead Computational Sciences design strategy across a diverse portfolio of discovery projects from hit expansion through lead optimisation. Design, evaluate, and prioritize molecules for synthesis using a complete suite of computational tools
Provide scientific leadership to multidisciplinary project teams from hit-finding to candidate selection
Drive the application of modern CADD approaches (AI/ML, SBDD, cheminformatic) across small molecule and other modalities
Build and enhance computational infrastructure, tools and capabilities
Collaborate closely with global Computational Chemistry teams and cross-functional stakeholders
Build and strengthen client relationships, supporting business growth and long-term collaborations
Contribute to departmental strategy, innovation, capability development and business proposals
Represent Pharmaron externally, enhancing reputation within the Computational Sciences and broader drug discovery communities

About You

PhD in Computational Chemistry, Theoretical Chemistry, Molecular Modelling or related discipline
10+ years’ experience in computational drug discovery (Pharma, Biotech or CRO)
Proven track record delivering impact across drug discovery pipelines and key milestones
Expertise across CADD approaches, including SBDD, AI/ML and cheminformatics
Experience working across modalities (small molecules, peptides, biologics, emerging platforms)
Strong publication and/or patent record
Demonstrated experience leading multidisciplinary teams and external collaborations
Excellent communication skills

Key Skills

Deep knowledge of computational chemistry in drug discovery
Strong understanding of medicinal chemistry, biology and DMPK integration
Excellent communication and stakeholder influencing skills
Ability to manage multiple complex programmes in parallel

Key Attributes

Strategic thinker with the ability to translate vision into execution
Inspirational leader and team developer
Collaborative, adaptable and culturally aware
Results-driven with strong client focus
Passionate about innovation, continuous learning and scientific excellence

Why Join Pharmaron?

Lead cutting-edge computational science within a global CRO
Influence strategy, capability build and scientific direction
Work on diverse, high-impact discovery programmes
Collaborate with world-class global teams

If you're ready to take a leadership role in advancing cheminformatics and computational chemistry, we’d love to hear from you.

Quick apply

Refine Your Search

senior principal scientist jobs in london se1

Senior Principal Scientist / Director – Computational Chemistry (IDD)

Principal Data Scientist

MRI Principal Clinical Scientist

Senior/Principal Project Manager - Renewables

Senior/Principal Platform Engineer

Senior Technologist - CTP London Threat Mitigation Technologies

Senior Principal AI Engineer

Senior/Principal Wind Energy Yield Analyst

Senior / Principal Civil 3D Modeller

Senior Principal AI Engineer

Chemistry Principal Scientist

Principal Data Scientist I

Principal Product Manager

Principal Data Scientist I

Assistant Technologies Manager, Sequencing Scientist and Deputy Institute Safety Officer

Principal Data Scientist I

Director, Preclinical External Innovation

Senior/Principal Hydrogeologist

Principal Data Scientist

Director, Preclinical External Innovation

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