Principal scientist Work, Jobs in Macclesfield (with Salaries)

Associate Principal Scientist – Peptide Development Chemistry - Pharmaceutical Sciences (PS)
AstraZeneca —Macclesfield
- Doctoral degree
- Master's degree
- Leadership
1d
Principal Data Scientist
Parliamentary and Health Service Ombudsman —Manchester
- £58,178 - £64,501 a year
- Full-time
- Hybrid work
- Azure
- Doctoral degree
- Master's degree
- Annual leave
- Employee assistance programme
2d
Principal Water Quality Scientist/ Modeller
AECOM —Manchester
- Full-time
- Hybrid work
- Master's degree
- Project management
- Scripting
Principal Data Scientist
National Westminster Bank PLC —Manchester
- Full-time
- Hybrid work
- Data analysis skills
- Machine learning
- Leadership
- Annual leave
1d
Principal Development Scientist
Waters Corporation —Wilmslow
- Doctoral degree
- Engineering
- Analysis skills
4d
Principal Data Scientist and Machine Learning Researcher (eDV)
Frontier Resourcing —Manchester
- Full-time
- Hybrid work
- Azure
- Doctoral degree
- Master's degree
Quick apply
Principal Clinical Scientist
The Christie NHS Foundation Trust —Manchester
- £57,528 - £64,750 a year
- Weekend availability
- Travel
1d
Lead Principal Clinical Scientist (Diagnostic Radiology and Radiation Protection)
The Christie NHS Foundation Trust —Manchester
- £66,582 - £77,368 a year
- Full-time
- Leadership
Principal Ecologist - BNG Specialist
AECOM —Manchester
- Full-time
- Hybrid work
Principal Consultant - Water Quality
APEM —Stockport
- Remote
- IT
- Leadership
- Communication skills
Principal / Associate Environmental Consultant
Pell Frischmann —Manchester
- Full-time
- Hybrid work
- Assembly
- Analysis skills
- Organisational skills
Principal Consultant - Freshwater Fisheries
APEM —Stockport
- Remote
- Mentoring
- Communication skills
Freshwater Fisheries Consultant
APEM —Stockport
- Remote
Senior/Principal Hydrogeologist
AECOM —Manchester
- Full-time
- Hybrid work
- Master's degree
- Bachelor's degree

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Associate Principal Scientist – Peptide Development Chemistry - Pharmaceutical Sciences (PS)

AstraZeneca -
Macclesfield

Apply Now

Job details

1 day ago

Benefits

Company pension

Qualifications

Doctoral degree
Master's degree
Project leadership
Leadership

Full job description

Location Macclesfield, England, United Kingdom Job ID R-256579 Date posted 16/07/2026

Associate Principal Scientist – Peptide Development Chemistry - Pharmaceutical Sciences (PS)

Location: Macclesfield, UK

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

Come and join our AZ team where you will play a pivotal role in this exciting period of development!!

Pharmaceutical Sciences is a function within the AstraZeneca Biopharmaceuticals R&D unit that builds innovative, efficient solutions by transforming molecules into investigative medicines meeting unmet needs of future patients. Early Chemical Development (ECD) is CMC department with responsibility for early phase Drug Substance. The department’s responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical material, and its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Design, Process Engineering, Route Design and Separation Science.

We’re looking for a highly experienced Process Chemist to join the team working on our peptide-containing clinical programs. These programs include pure-play therapeutic peptide projects, as well as projects involving peptide conjugates (such as antibody-peptide conjugates and oligonucleotide-peptide conjugates). The role will sit within ECD’s New Modalities team, with a focus on delivering against our TIDES-based early clinical-phase project portfolio, working closely with our CMC Project Leaders and in collaboration between our late-phase development teams and our internal Discovery TIDES colleagues. The individual will have extensive process chemistry development, manufacturing and project leadership experience, and this must include considerable expertise in developing peptide chemistry for CMC applications. A passion for working in new / emerging scientific areas and developing solutions to technical and project challenges is a key requirement for the role.

Key Responsibilities:

As a project technical lead for Early Chemical Development, working on complex peptide and peptide-conjugate drug projects, you will drive the development and manufacture of these peptide-containing drug substances, contributing significantly to the definition and implementation of manufacturing strategies for API processes, driven primarily through external partnership with our CMDOs

Demonstrate scientific leadership, contribute strategic thinking and provide expert challenge within peptide (and peptide-conjugate) drug project CMC teams, whilst role modelling positive behaviours in exploring new ways of working and accelerating scientific development in both projects and the department

Bring an outward-facing perspective towards addressing opportunities (collaborating with across functional and departmental boundaries, identifying/aligning specialist capabilities, identifying and tapping into expertise external to AstraZeneca).

Mentor and develop colleagues, supporting them in reaching their full potential.

Enhance AstraZeneca’s scientific reputation by publishing research and engaging in external collaborations.

Requirements:

Degree or equivalent scientific qualification (Masters or PhD preferred) in a relevant field

Deep understanding of the drug development process, spanning discovery through to launch, with clear evidence of significant CMC project expertise

Significant direct experience of peptide-specific chemical development with a track record of delivery and creativity in leading drug substance development project work within a CMC organisation, with demonstrated ability to provide influence and strategic direction, deliver technical supervision (internally/externally) and provide mentorship to colleagues
Hand on experience of conjugation chemistry involving peptide linkers or peptide targeting agents.

Solid understanding of the regulatory environment for clinical development and supply of peptide and peptide-containing drug substance

Desirables:

Strong leadership skills, with excellent communication and strategic influencing ability, including experience of partnering with external CRO’s and CDMO’s

Strong development focus, of self and others, with an interest in learning about new scientific areas

Ability to think and operate across functional boundaries, challenge the status quo, and seek opportunities for business improvement

In Office Requirement:

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Competitive salary and benefits package on offer!

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Date Posted

17-Jul-2026

Closing Date

02-Aug-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Apply Now

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principal scientist jobs in macclesfield

Associate Principal Scientist – Peptide Development Chemistry - Pharmaceutical Sciences (PS)

Principal Data Scientist

Principal Water Quality Scientist/ Modeller

Principal Data Scientist

Principal Development Scientist

Principal Data Scientist and Machine Learning Researcher (eDV)

Principal Clinical Scientist

Lead Principal Clinical Scientist (Diagnostic Radiology and Radiation Protection)

Principal Ecologist - BNG Specialist

Principal Consultant - Water Quality

Principal / Associate Environmental Consultant

Principal Consultant - Freshwater Fisheries

Freshwater Fisheries Consultant

Senior/Principal Hydrogeologist

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