Principal data scientist Work, Jobs in Manchester (with Salaries)

Principal Scientist I – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Senior Data Scientist
Informed Solutions —Altrincham
- Hybrid work
- Azure
- Doctoral degree
- Master's degree
- Gym membership
- Referral programme
Quick apply
Wildcard - Apply Now!
ONYX Insight —Manchester
- Full-time
Quick apply
Principal Consultant - Water Quality
APEM —Stockport
- Remote
- IT
- Leadership
- Communication skills
4d
Principal Scientist / Associate Scientific Director – Computational Chemistry
Concept Life Sciences —Chapel en le Frith
- Full-time
- Hybrid work
- Doctoral degree
- Leadership
- Free parking
Principal Architect
AECOM —Manchester
- Full-time
- Hybrid work
- AutoCAD
- Microsoft Office
- Communication skills
3d
Principal Ecologist - BNG Specialist
AECOM —Manchester
- Full-time
- Hybrid work
Senior Scientist II – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Principal Mechanical Engineer - Data Centres
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Project management
- Presentation skills
Principal Civil Engineer
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Leadership
Principal Dams & Reservoir Engineer
AtkinsRéalis —Manchester
- Full-time
- Hybrid work
- Construction
- Communication skills
13d
Advisory Senior Consultant
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Analysis skills
- Continuous improvement
10d
Data Architect
PA Consulting —Manchester
- Full-time
- Hybrid work
- Azure
- Mentoring
- AI
- Annual leave
Quick apply
Principal Market Development Specialist
Waters Corporation —Wilmslow
- Hybrid work
- Sales
- Business development
- Bachelor's degree
Principal Nuclear Project Planner
AECOM —Warrington
- Full-time
- Hybrid work
- Analysis skills
- Communication skills
Senior Clinical Psychologist
Mersey Care NHS Foundation Trust —Leyland
- £57,528 - £64,750 a year
- Full-time
- Doctoral degree
- Microsoft Office
- Care plans
9d
Senior/ Principal Transport Planner
AECOM —Manchester
- Full-time
- Hybrid work
- Master's degree
- Business development
- Project management
Lead Machine Learning Engineer (Manchester)
Fitch Group —Manchester
- Azure
- Java
- Master's degree
Principal Hydrologist
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Data analysis skills
- Master's degree
Senior Planner - Highways
AECOM —Manchester
- Full-time
- Hybrid work
- Civil engineering
- Leadership

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Principal Scientist I – LC-MS/MS

Synexa Life Sciences
Macclesfield

Quick apply

Job details

Full-time

Qualifications

Doctoral degree
Master's degree
HRIS
FDA regulations

Full job description

Role Overview

We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

Provide scientific leadership and SME support across LC-MS/MS studies
Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
Advise on method development, optimisation, and validation strategies
Support study teams in resolving technical issues and ensuring consistent assay performance
Contribute to client interactions, including scientific discussions, data interpretation, and method justification
Support proposals, bid defences, and scientific strategy discussions
Mentor and support development of laboratory scientists

Technical Expertise

Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

Peptides and proteins
Oligonucleotides
Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

Extensive experience working under GLP and GCP
Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
Experience supporting audits and regulatory inspections
Proven ability to lead scientific discussions with clients and defend analytical approaches and data
Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

PhD in Analytical Chemistry or related field, or MSc with significant industry experience
10 to 15 or more years of LC-MS/MS bioanalysis experience
Demonstrated expertise in method development, validation, and advanced troubleshooting

Quick apply

Refine Your Search

principal data scientist jobs in manchester

Principal Scientist I – LC-MS/MS

Senior Data Scientist

Wildcard - Apply Now!

Principal Consultant - Water Quality

Principal Scientist / Associate Scientific Director – Computational Chemistry

Principal Architect

Principal Ecologist - BNG Specialist

Senior Scientist II – LC-MS/MS

Principal Mechanical Engineer - Data Centres

Principal Civil Engineer

Principal Dams & Reservoir Engineer

Advisory Senior Consultant

Data Architect

Principal Market Development Specialist

Principal Nuclear Project Planner

Senior Clinical Psychologist

Senior/ Principal Transport Planner

Lead Machine Learning Engineer (Manchester)

Principal Hydrologist

Senior Planner - Highways

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