Senior principal scientist Work, Jobs in Nazeing, Ess (with Salaries)

Senior Principal Scientist / Director – Computational Chemistry (IDD)
Pharmaron —Hoddesdon
- Remote
- Doctoral degree
- AI
- Leadership
Principal Data Scientist
CoMind —London
- £152,000 - £190,000 a year
- Full-time
- IT
- AI
- Leadership
- Employee discount
Senior Researcher
Nesta —London
- £50,700 - £67,800 a year
- Hybrid work
- Master's degree
- Analysis skills
- Bachelor's degree
- Annual leave
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Head of Data Science (Principal Data Scientist)
Guy's and St Thomas' NHS Foundation Trust —London
- £88,250 - £100,355 a year
- Full-time
- Doctoral degree
- Master's degree
- SQL
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Principal Data Scientist | Media Measurement (MM)
NielsenIQ —London
- £90,000 - £112,000 a year
- Full-time
- Hybrid work
- Doctoral degree
- Master's degree
- AI
- Employee assistance programme
Quick apply
1d
Senior Principal AI Engineer
Synapri —London
- £90,000 - £120,000 a year
- Hybrid work
- Azure
- AWS
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Senior Data Scientist
Informed Solutions —London
- Hybrid work
- Azure
- Doctoral degree
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- Gym membership
- Referral programme
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Senior/Principal Project Manager - Renewables
AECOM —London
- Full-time
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- Engineering
- Bachelor's degree
Senior/Principal Wind Energy Yield Analyst
AECOM —London
- Full-time
- Hybrid work
- Engineering
- Data analysis skills
- Master's degree
Principal Data Scientist
marshmallow —London
- Full-time
- Hybrid work
- Machine learning
- AI
- Communication skills
Principal Hydrologist
AECOM —St Albans
- Full-time
- Hybrid work
- Engineering
- Data analysis skills
- Master's degree
Data Scientist (Portfolio Analytics)
Lloyd's of London —London
- Full-time
- Hybrid work
- SQL
- Communication skills
- Python
- Employee discount
- Gym membership
Data Scientist - Principal
Product Madness —London
- Full-time
- Azure
- Doctoral degree
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Chemistry Principal Scientist
Substrate Bio —London
- Full-time
- Hybrid work
- Doctoral degree
- AI
- Annual leave
Quick apply
Principal Product Manager
Gigaton —London
- £100,000 - £130,000 a year
- Full-time
- Hybrid work
- Travel
- AI
Quick apply
MRI Principal Clinical Scientist
University College London Hospitals NHS Foundation Trust —London
- £75,328 - £86,114 a year
- Full-time
- University
- Leadership
Principal Data Scientist I
RELX —London
- Full-time
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Molecular Characterisation Scientist, Biologics
Substrate Bio —London
- Full-time
- Doctoral degree
- Laboratory experience
- Master's degree
- Annual leave
Quick apply
8d
Senior / Principal Civil 3D Modeller
AECOM —London
- Full-time
- Hybrid work
- AutoCAD
- Civil engineering
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Senior AI Engineer | Freelance
Elsewhen —London
- £500 - £600 a day
- Remote
- Master's degree
- SQL
- Machine learning
4d

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senior principal scientist jobs near nazeing, ess

Senior Principal Scientist / Director – Computational Chemistry (IDD)

Pharmaron -
Hoddesdon

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Job details

Permanent

Qualifications

Doctoral degree
AI
Leadership
Communication skills

Full job description

Job Introduction

Senior Principal Scientist / Director – Computational Chemistry (IDD)

Location: UK – Remote

About Pharmaron

Pharmaron is a global contract research and manufacturing organization (CRO/CDMO) helping pharma and biotech companies bring new therapies to life. With over 25,000 employees worldwide across 28 locations in the UK, US, China, and Singapore, we support drug discovery through to manufacturing with fully integrated high-quality services.

We're proud of the impact we make and just last year, we supported 887 discovery projects, 1,100+ CMC programs, and 1,397 clinical trials across all phases. Our teams are involved in everything from small molecules, ADC's, biologics, and gene therapies and we work with more than 3,300 global customers. To learn more, visit www.pharmaron.com.

Pharmaron is looking for a Senior Principal Scientist / Director – Computational Chemistry to lead on the design and optimisation of multi-modality ligands within our Integrated Drug Discovery programmes and help shape our Computational Sciences capability.

This is a senior role requiring scientific excellence, and client engagement to drive integrated, multi-modality drug discovery programmes.

The Integrated Drug Discovery (IDD) Services group at Pharmaron is responsible for leading and delivering drug discovery projects for our client partners. The team comprises scientific expertise and strategic leadership across medicinal chemistry, CADD, biology, DMPK and translational science. Combined with Pharmaron’s global research capabilities, we design and deliver integrated programmes from target identification and hit finding, through to IND filing. Working closely with our partners, we define strategy, coordinate execution across teams and, with an AI enabled accelerated Design–Make–Test–Analyse cycle, support the progression of projects and innovative medicines towards the clinic.

The Role

Lead Computational Sciences design strategy across a diverse portfolio of discovery projects from hit expansion through lead optimisation. Design, evaluate, and prioritize molecules for synthesis using a complete suite of computational tools
Provide scientific leadership to multidisciplinary project teams from hit-finding to candidate selection
Drive the application of modern CADD approaches (AI/ML, SBDD, cheminformatic) across small molecule and other modalities
Build and enhance computational infrastructure, tools and capabilities
Collaborate closely with global Computational Chemistry teams and cross-functional stakeholders
Build and strengthen client relationships, supporting business growth and long-term collaborations
Contribute to departmental strategy, innovation, capability development and business proposals
Represent Pharmaron externally, enhancing reputation within the Computational Sciences and broader drug discovery communities

About You

PhD in Computational Chemistry, Theoretical Chemistry, Molecular Modelling or related discipline
10+ years’ experience in computational drug discovery (Pharma, Biotech or CRO)
Proven track record delivering impact across drug discovery pipelines and key milestones
Expertise across CADD approaches, including SBDD, AI/ML and cheminformatics
Experience working across modalities (small molecules, peptides, biologics, emerging platforms)
Strong publication and/or patent record
Demonstrated experience leading multidisciplinary teams and external collaborations
Excellent communication skills

Key Skills

Deep knowledge of computational chemistry in drug discovery
Strong understanding of medicinal chemistry, biology and DMPK integration
Excellent communication and stakeholder influencing skills
Ability to manage multiple complex programmes in parallel

Key Attributes

Strategic thinker with the ability to translate vision into execution
Inspirational leader and team developer
Collaborative, adaptable and culturally aware
Results-driven with strong client focus
Passionate about innovation, continuous learning and scientific excellence

Why Join Pharmaron?

Lead cutting-edge computational science within a global CRO
Influence strategy, capability build and scientific direction
Work on diverse, high-impact discovery programmes
Collaborate with world-class global teams

If you're ready to take a leadership role in advancing cheminformatics and computational chemistry, we’d love to hear from you.

Salary Competitive
Frequency Annual
Job Reference ukpharmaron/TP/141/688
Contract Type Permanent Contract
Closing Date No expiry date
Job Category Scientific (CADD)
Division Drug Discovery
Location Hoddesdon, United Kingdom
Posted on 11 June, 2026

Apply Now

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senior principal scientist jobs in nazeing, ess

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