We are seeking a highly experienced, motivated and innovative individual to join us as a Principal Scientist or Senior Principal Scientist in the Translational Genetics team, which is part of the broader GSK R&D Translational Sciences group.The successful candidate will provide a deep and broad skillset in statistical and computational methods to identify, develop and deliver a portfolio of translational data-driven activities to impact the GSK portfolio. You will have strong expertise in analysing large-scale genetic and ‘omics datasets, with a particular emphasis on interpreting findings from these efforts to help develop understanding into causal mechanisms in disease. Your work will have application across therapeutic areas and may inform target discovery, biomarker discovery, disease and mechanistic understanding, indication and patient subgroup selection, and parsing treatment response using precision medicine approaches.The successful candidate will work within a multidisciplinary, collaborative and scientifically driven environment interacting with GSK scientists to advance drug discovery and clinical development. You may have the opportunity to drive collaborations with external institutions aligned with strategic priorities.Additionally, you will be encouraged and supported in your ongoing scientific development through your impactful work and its visibility to key stakeholders, completing development programmes, presenting your research and writing peer-reviewed publications.We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpage <a href="https://www.gsk.com/en-gb/careers/life-at-gsk/" target="_blank"><i>Life at GSK | GSK</i></a><b>In this role you will </b>Applying state-of-the-art statistical and computational approaches to large-scale genetic, genomic (including proteomics) and clinical phenotypic datasets to generate at-scale insights and address targeted translational scientific questions.Demonstrate analytical prowess to develop, and deliver high quality work to impact the GSK drug development pipeline.Effectively communicate analysis findings, with expert interpretation, to GSK Genetics & Genomics colleagues and project teams.Work with focus and agility to deliver personal and team deliverables against objectives, demonstrating strong statistical, analytic and critical thinking skills with understanding of the translational context of your work.Stay informed about emerging technologies and methodologies in translational and statistical genetics with evaluation of their potential and implementation in the organization as indicated.Contribute to a culture of innovation, collaboration, and continuous professional learning within the team.<b><i>Why you?</i></b><b>Basic Qualifications & Skills:</b><b>We are looking for professionals with these required skills to achieve our goals:</b>PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics or machine learning) with either a history or demonstrably working towards impactful scientific publications and/or presentations.Experienced in genetics and conducting analyses that integrate genetics, genomics (particularly proteomics) and/or clinical phenotypic data to address translational questions in drug discovery and development.Excellent programming skills in R or python, and knowledge of techniques in reproducible research, literate programming, FAIR data principles, or software development.Ability to assess and implement new methodologies and approaches to integrate genetics and genomics to answer translational questions in drug discovery and development.Demonstrated ability to understand key scientific questions of relevance to drug discovery and development and identify and develop innovative analytical solutions to answer them.Demonstrated experience in effectively communicating complex scientific concepts to scientific colleagues.<b>Preferred Qualifications & Skills:</b><b>Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:</b>Excellent collaboration and partnership skills to work effectively with internal stakeholders across functions.Experience working in multidisciplinary teams on complex and impactful projects.Experience of working in different trusted research environments (TREs)Demonstrated ability to work effectively both independently and in multidisciplinary teams to meet work timelines.Familiarity with the stages of drug discovery and development<b>Closing Date for Applications – 6th July 2026 (COB)</b>Please take a copy of the Job Description, as this will not be available post closure of the advert. <br />When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.Find out more: <a href="https://www.gsk.com/en-gb/innovation/" target="_blank">Our approach to R&D</a>. <b>Why GSK?</b><b>Uniting science, technology and talent to get ahead of disease together.</b>GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at <a target="_blank" href="mailto:UKRecruitment.Adjustments@gsk.com"><span style="color:#0000ff"><u>UKRecruitment.Adjustments@gsk.com</u></span></a> where you can also request a call.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the <a target="_blank" href="https://www.gsk.com/en-gb/locations/united-kingdom/"><span style="color:#0000ff"><u>Link</u></span></a> where you will find answers to multiple questions we receive<b>Important notice to Employment businesses/ Agencies</b>GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at <a target="_blank" href="https://openpaymentsdata.cms.gov/"><span style="color:#0000ff"><u>https://openpaymentsdata.cms.gov/</u></span></a>
