Ref Number
B02-10858
Professional Expertise
Research and Research Support
Department
School of Life & Medical Sciences (B02)
Location
London
Working Pattern
Full time
Salary
£54,931-£64,644
Contract Type
Fixed-term
Working Type
Hybrid
Available for Secondment
No
Closing Date
20-Jul-2026
Our mission is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award. Please only attach relevant documents to your application (qualifications, cover letters, supporting statements) and avoid attaching large files e.g. research papers, thesis, publications etc.
An experienced Senior Research Fellow is required for projects developing the next generation of therapies for children with blood and immune disorders, including CAR T cells for leukaemia. The postholder will design, generate and investigate strategies to improve CAR T cell and haematopoietic stem cell therapies in pre-clinical studies. They will also require experience in human cell engineering using techniques such as RNA-guided editing and lentiviral transduction. There will be close working with university and hospital partners, and supervision of junior staff and students. Team working, aptitude and excellent communication and record keeping skills will be essential. The postholder will have skills for investigating genome editing of T cells/haematopoietic stem cells, high throughput and single cell analysis and humanised models. This is exciting opportunity in a rapidly emerging area of translational medicine. The post is funded by GOSHCC and will be appointed for 12 months in the first instance with scope for extension.
The successful candidate is expected to have the following; Expertise in human T cell and/or stem cell handling, culture, genome editing, flow cytometry, and functional assays. Skills for humanised models of adoptive therapy and stem cell engraftment. Experience in the design and testing of genome editing tools (CRISPR/Cas, base and prime editing) and associated sequencing and bioinformatics. Experience with NGS, WGS and single-cell RNA analysis (scRNA). Ability to handle and interpret sequencing and single-cell datasets. Established record of PhD supervision to completion.
As well as the exciting opportunities this role presents we also offer some great benefits some of which are below: 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan On-Site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance
As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/
