Job Title: Senior Research Scientist – Protein Scientist
Location: Cambridge, UK
Salary: Competitive with excellent benefits!
Introduction to the Role:
Biologics Engineering Function in the UK is based at our new state-of-the-art Discovery Centre (DISC) located on the Cambridge Biomedical Campus. Biologics Engineering is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.
About the Role
We are seeking a highly motivated Senior Scientist to join Biologics Engineering within the Protein Sciences & Analytics (PS&A) team, supporting the generation of Bioconjugates. AstraZeneca are looking to strengthen capability in conjugation workflows and enable data-driven optimisation of bioconjugate design and production.
The successful candidate will combine hands-on conjugation expertise with strong analytical and data science capabilities, working at the interface of protein science, chemistry, and computational analysis.
Accountabilities:
Express, purify, and characterize antibodies and protein constructs (IgG, VHH, fusion proteins) to support conjugation workflows.
Execute analytical QC for conjugates and proteins using SEC, HIC, RP‑HPLC, LC‑MS, and SDS‑PAGE; ensure data integrity and timely reporting.
Main Duties & Responsibilities
Education & Experience Requirements
- PhD in Biochemistry, Structural Biology, Chemical Biology or related discipline.
- Strong foundation in protein expression, purification, and characterization; experience with bioconjugation is highly desirable.
- Familiarity with analytical techniques (SEC, HIC, RP-HPLC, LC‑MS) and data interpretation.
Required Skills
Hands‑on experience in protein biochemistry: expression systems (mammalian, bacterial), purification (affinity, ion exchange, size exclusion), and QC.
Desired Skills
Why AstraZeneca:
AstraZeneca is a science-led, global biopharmaceutical company, with a focused portfolio in core therapies. At AstraZeneca we turn ideas into life changing medicines. We are committed to improving the health and lives of people across the globe, through our research and development platform, and a growing late-stage pipeline. Working in over 100 countries, we have strength in emerging markets, and our medicines are used by millions of patients and clinicians worldwide. Working here means being results-oriented and working together to make the impossible a reality.
Here you will apply cutting-edge biophysics, automation, and AI-enabled analytics to help transform the future of cancer treatment. We unite decisive, science-driven teams who act fast on smart risks, speak up, and challenge convention—always guided by evidence. With a deep pipeline and unparalleled data, you will collaborate with diverse experts, learn across disciplines, and see your work directly influence how new medicines move forward. We value kindness alongside ambition, and we bring unexpected teams together to unleash bold thinking that turns complex problems into meaningful progress for patients.
So, what's next?
Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
Where can I find out more?
Our Social Media,
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Date Posted
03-Jun-2026
Closing Date
16-Jun-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
