Senior principal Work, Jobs in Chelmsford, Ess (with Salaries)

Senior Principal Scientist / Director – Computational Chemistry (IDD)
Pharmaron —Hoddesdon
- Remote
- Doctoral degree
- AI
- Leadership
Quick apply
Senior/Principal Systems Engineer - CUAS
Leonardo UK Ltd —Basildon
- Full-time
- Hybrid work
- Engineering
- System design
- No degree
- Flexible schedule
- Referral programme
14d
Senior Change Manager
Hiscox —Colchester
- Part-time
- Organisational skills
- Agile
2d
Head of Governance, Risk and Compliance
Call Assist —Colchester
- Full-time
- Research
- Travel
- Contracts
- Work from home
- Employee discount
Quick apply
14d
Warehouse & Production Technician
KI Sound & Light Limited —Braintree
- £26,000 - £29,000 a year
- Overtime
- Computer literacy
- Maintenance
- Organisational skills
Quick apply
Senior Lab Manager
Azelis —Hertford
- Full-time
- English
- Master's degree
- Analysis skills
Senior/Principal Civil Infrastructure Engineer (Development)
WSP —Hertford
- Part-time
- Hybrid work
- Civil engineering
- Mentoring
- Training & development
- Flexitime
- Work from home
PCB Sales Manager
Pulsar Measurement —Earls Colne
- £60,000 - £70,000 a year
- Hybrid work
- CRM software
- Engineering
- Business development
- Employee discount
- Sick pay
Quick apply
Head of Estates
Enfield Council —Enfield
- £88,944 - £107,535 a year
- Management
- Presentation skills
- IT
- Annual leave
- Employee assistance programme
11d
Principal / Lead Systems Engineer
Leonardo UK Ltd —Basildon
- Full-time
- Hybrid work
- Agile
- Leadership
- Communication skills
- Flexible schedule
- Referral programme
Training Coordinator
Gallifordtry —Romford
- Part-time
- Microsoft Powerpoint
- Microsoft Word
- Customer service
- Employee assistance programme
- Employee discount
Butchery General Manager
Thomas Joseph Butchery —Brentwood
- £37,500 - £45,000 a year
- Full-time
- Inventory control
- Continuous improvement
- Mentoring
- Store discount
- Employee discount
Quick apply
Executive Assistant
Executive Support —Colchester
- £28,687 - £31,284 a year
- Full-time
- Microsoft Powerpoint
- Microsoft Word
- Microsoft Outlook
Quick apply
7d
Senior Software Engineer
Investa —London
- £85,000 - £105,000 a year
- Full-time
- Hybrid work
- Annual leave
Quick apply
Design Lead
UK Power Networks —West Ham
- £99,127 a year
- Hybrid work
- Microsoft Powerpoint
- Management
- Analysis skills
- Annual leave
- Employee assistance programme
10d
Senior Care Assistant
Caremark - Home Care in Havering —Havering-atte-Bower
- Part-time
- Quality control
- Travel
Principal Psychologist
PPG Health In Justice —London
- Up to £82,000 a year
- Monday to Friday
- Management
- Research
- Patient care
- Employee discount
PRINCIPAL ESTIMATOR
Laing O'Rourke —Dartford
- Continuous improvement
- Mentoring
- Training & development
PRINCIPAL ENGINEER
Laing O'Rourke —Dartford
- Civil engineering
- Team management
- Mentoring
Transport Assistant
MTS Cleansing Services LTD —Rochester
- £31,473 a year
- Full-time
- Microsoft Word
- Microsoft Excel
- Microsoft Office
- Free parking
- Health & wellbeing programme
Quick apply

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Senior Principal Scientist / Director – Computational Chemistry (IDD)

Pharmaron -
Hoddesdon

Quick apply

Job details

Qualifications

Doctoral degree
Stakeholder collaboration
Client engagement
Stakeholder liaison
Partnership building
Relationship management
Multidisciplinary collaboration
AI
Project leadership
Leadership
Communication skills

Full job description

Job Introduction

Senior Principal Scientist / Director – Computational Chemistry (IDD)

Location: UK – Remote

About Pharmaron

Pharmaron is a global contract research and manufacturing organization (CRO/CDMO) helping pharma and biotech companies bring new therapies to life. With over 25,000 employees worldwide across 28 locations in the UK, US, China, and Singapore, we support drug discovery through to manufacturing with fully integrated high-quality services.

We're proud of the impact we make and just last year, we supported 887 discovery projects, 1,100+ CMC programs, and 1,397 clinical trials across all phases. Our teams are involved in everything from small molecules, ADC's, biologics, and gene therapies and we work with more than 3,300 global customers. To learn more, visit www.pharmaron.com.

Pharmaron is looking for a Senior Principal Scientist / Director – Computational Chemistry to lead on the design and optimisation of multi-modality ligands within our Integrated Drug Discovery programmes and help shape our Computational Sciences capability.

This is a senior role requiring scientific excellence, and client engagement to drive integrated, multi-modality drug discovery programmes.

The Integrated Drug Discovery (IDD) Services group at Pharmaron is responsible for leading and delivering drug discovery projects for our client partners. The team comprises scientific expertise and strategic leadership across medicinal chemistry, CADD, biology, DMPK and translational science. Combined with Pharmaron’s global research capabilities, we design and deliver integrated programmes from target identification and hit finding, through to IND filing. Working closely with our partners, we define strategy, coordinate execution across teams and, with an AI enabled accelerated Design–Make–Test–Analyse cycle, support the progression of projects and innovative medicines towards the clinic.

The Role

Lead Computational Sciences design strategy across a diverse portfolio of discovery projects from hit expansion through lead optimisation. Design, evaluate, and prioritize molecules for synthesis using a complete suite of computational tools
Provide scientific leadership to multidisciplinary project teams from hit-finding to candidate selection
Drive the application of modern CADD approaches (AI/ML, SBDD, cheminformatic) across small molecule and other modalities
Build and enhance computational infrastructure, tools and capabilities
Collaborate closely with global Computational Chemistry teams and cross-functional stakeholders
Build and strengthen client relationships, supporting business growth and long-term collaborations
Contribute to departmental strategy, innovation, capability development and business proposals
Represent Pharmaron externally, enhancing reputation within the Computational Sciences and broader drug discovery communities

About You

PhD in Computational Chemistry, Theoretical Chemistry, Molecular Modelling or related discipline
10+ years’ experience in computational drug discovery (Pharma, Biotech or CRO)
Proven track record delivering impact across drug discovery pipelines and key milestones
Expertise across CADD approaches, including SBDD, AI/ML and cheminformatics
Experience working across modalities (small molecules, peptides, biologics, emerging platforms)
Strong publication and/or patent record
Demonstrated experience leading multidisciplinary teams and external collaborations
Excellent communication skills

Key Skills

Deep knowledge of computational chemistry in drug discovery
Strong understanding of medicinal chemistry, biology and DMPK integration
Excellent communication and stakeholder influencing skills
Ability to manage multiple complex programmes in parallel

Key Attributes

Strategic thinker with the ability to translate vision into execution
Inspirational leader and team developer
Collaborative, adaptable and culturally aware
Results-driven with strong client focus
Passionate about innovation, continuous learning and scientific excellence

Why Join Pharmaron?

Lead cutting-edge computational science within a global CRO
Influence strategy, capability build and scientific direction
Work on diverse, high-impact discovery programmes
Collaborate with world-class global teams

If you're ready to take a leadership role in advancing cheminformatics and computational chemistry, we’d love to hear from you.

Quick apply

Refine Your Search

senior principal jobs in chelmsford, ess

Senior Principal Scientist / Director – Computational Chemistry (IDD)

Senior/Principal Systems Engineer - CUAS

Senior Change Manager

Head of Governance, Risk and Compliance

Warehouse & Production Technician

Senior Lab Manager

Senior/Principal Civil Infrastructure Engineer (Development)

PCB Sales Manager

Head of Estates

Principal / Lead Systems Engineer

Training Coordinator

Butchery General Manager

Executive Assistant

Senior Software Engineer

Design Lead

Senior Care Assistant

Principal Psychologist

PRINCIPAL ESTIMATOR

PRINCIPAL ENGINEER

Transport Assistant

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