Lead site reliability engineer Work, Jobs in Thame, Oxf (with Salaries)

Staff Site Reliability Engineer
Genomics —Oxford
- Full-time
- Hybrid work
- Annual leave
2d
Manufacturing Engineer
John Crane —Slough
- Full-time
- Engineering
- Bachelor's degree
- Organisational skills
Quick apply
Engineering Team Leader
McCormick & Company —Haddenham
- Analysis skills
- Continuous improvement
- Team management
Lead Chemical Engineer (Gasoline)
Honeywell —Bracknell
- Full-time
- Engineering
- Presentation skills
- Bachelor's degree
3d
Continuous Improvement Engineer
Legrand Group —Reading
- Microsoft Powerpoint
- Engineering
- Bachelor's degree
- Annual leave
Quick apply
Principal Systems Engineer (Group Lead)
Martin-Baker —Denham
- Hybrid work
- Analysis skills
- Continuous improvement
- Training & development
- Annual leave
- Employee discount
Shift Engineer - Data Centres
JLL —Slough
- Communication skills
- Banking
- Annual leave
Lead Electrical and Controls Engineer
Lantmännen —Milton Keynes
- Programmable logic controllers
- Bakery
- Continuous improvement
Senior Process Project Engineer - Helium Recovery Infrastructure
Siemens Healthineers —Oxford
- Full-time
- Hybrid work
- PMP
- Engineering
- Continuous improvement
- Annual leave
1d
Garage Technicians & Jnr Garage Technicians (Event Support Crew)
Red Bull Technology Group —Milton Keynes
- Full-time
- Maintenance
10d
Systems Engineer
Infleqtion —Kidlington
- Full-time
- Hybrid work
- Doctoral degree
- Engineering
- Master's degree
- Annual leave
Quick apply
11d
Field Service Engineer
2G Energy Ltd —Milton Keynes
- From £22.86 an hour
- Full-time
- Customer service
- Maintenance
- Computer skills
- Health & wellbeing programme
- Employee discount
Quick apply
12d
Health and Safety Lead - Seat Test
Martin-Baker —Chalgrove
- Call to connect
- Training & development
- Leadership
- Annual leave
- Employee discount
Production Engineer - Optical & Semiconductor Systems
Infinitesima —Abingdon
- £43,000 - £50,000 a year
- Hybrid work
- Assembly
- Continuous improvement
- No degree
Quick apply
Head of Engineering - Quality
Wireless Logic mdex GmbH —Reading
- Hybrid work
- Leadership
- Communication skills
Unified Comms Manager
Smiths Detection —Hemel Hempstead
- Full-time
- Hybrid work
- Computer Science
- AWS
- Analysis skills
Quick apply
Shift Engineer - Data Centres
NAB-Jones Lang LaSalle Services —Slough
- Part-time
- In-person
- Communication skills
- Banking
- Annual leave
Quick apply
Electronics Design Lead (Multiple Locations)
ALTEN —Reading
- £50,000 - £65,000 a year
- Full-time
- Military
- Engineering
- Master's degree
- Employee assistance programme
- Life insurance
Quick apply
Senior Automation Engineer, Laboratory Automation & Biobanking
Moderna, Inc. —Oxford
- Full-time
- Computer Science
- Engineering
- Master's degree
- Annual leave
Digital & IT Senior Analyst - Messaging
Parker Hannifin Corporation —Hemel Hempstead
- Computer Science
- Maintenance
- Bachelor's degree

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lead site reliability engineer jobs near thame, oxf

Staff Site Reliability Engineer

Genomics -
Oxford

Apply Now

Job details

Full-time
2 days ago

Benefits

Annual leave
Company pension
Private medical insurance

Full job description

Location: Oxford or London (Hybrid)

The Mission: Why We Exist

Genomics is a science-led transatlantic TechBio combining large-scale genetic and health data with proprietary analytics to accelerate drug discovery and advance predictive, preventative healthcare. We are united by a single vision to help people live longer healthier lives, using the power of genomics.

Genomics aims to help people live longer, healthier lives in two ways: super-charging drug discovery and development for novel treatments with our AI-enabled advanced genetic analytics platform, and by helping people understand their personal risk of common chronic diseases through polygenic risk scores - giving doctors and health systems the chance to get the right people into the right prevention, screening and treatment programmes at the right time.

Role Purpose

Genomics runs on multi-trillion-row, petabyte-scale genetic and health data. Mystra is the analytical data platform that makes that usable, and MystraAI is the agentic layer we are building on top of it. This is a Staff-level role that owns the reliability, performance, security and integrity of that infrastructure end-to-end — and sets the technical direction that other teams build on.

You will lead the analytical data platform and our Data-as-a-Service offering, shape the data foundations behind MystraAI, and line-manage a small team of engineers while staying deeply hands-on. If you want your work to sit at the intersection of large-scale infrastructure and genuinely meaningful science, this is it.

A Day in the Life

The role spans the full depth of the platform — from low-level infrastructure reliability and database internals up to the systems that serve data across the product. On any given day you might be:

Architecting, tuning and operating multi-tenant ClickHouse or equivalent OLAP database clusters at multi-trillion-row, petabyte scale — sharding and replication, materialised views, merge and query optimisation, tenant isolation and cost/performance trade-offs.
Owning SLOs, observability, capacity planning and incident response for data-intensive systems and pipelines, alongside the orchestration and job execution that power them.
Shaping Data-as-a-Service as a real product — a secure, multi-tenant, immutable release architecture, with data made discoverable at scale through catalogue and ontology-driven search, in partnership with the data team.
Powering agentic AI from the data platform — scaling the data foundations behind MystraAI and owning secure, tenant-scoped access for agents, partnering closely with the ML team on how our AI systems perform.
Treating security as a first-class architectural concern — tenant isolation, secrets and credential management, and least-privilege access to systems, tools and data.
Setting technical direction, mentoring and line-managing a small team of IC2/IC3 engineers, and influencing decisions well beyond your own team.

Who You Are

You are a recognised specialist who leads through expertise — principal-level individual-contributor depth combined with the judgement to set standards others follow. You will bring:

Large-scale OLAP / ClickHouse. Deep experience designing and tuning multi-tenant ClickHouse at extreme scale. You engage with the engine at source level rather than as a black box — and ideally have contributed code upstream.
Reliability engineering for data platforms. You bring true SRE discipline — SLOs, observability, capacity planning and incident response — to analytical data systems and pipelines.
Data-as-a-Service productisation. You think in terms of data as a product: secure, multi-tenant, immutable releases, and discoverability at scale.
Agent-ready data. You understand what it takes to expose platform data to agents safely and at scale — access patterns, tenant isolation, sensible guardrails — and have scaled data infrastructure under demanding workloads.
Multi-tenant security. You design for isolation, least-privilege access and sound secrets management from the outset.
Technical leadership. You drive direction and innovation across a platform, mentor engineers, and can line-manage a small team without losing your own hands-on edge.

Your Package

We are committed to providing a transparent, supportive, and rewarding work environment.

Compensation & Growth

Competitive Salary: Salaries are externally benchmarked annually to ensure top-of-market compensation.
Clear Career Path: A straightforward, open progression framework means you'll always know the path to promotion and how to achieve your next career goal.
Continuous Learning: Including external courses and a wide library of L&D materials, because your growth is our success.

Wellbeing & Time Off

Holiday: 25 days annual leave, plus bank holidays, plus an extra 3-day company-wide shutdown at year-end.
Financial & Health Security: Robust benefits including a market-leading pension scheme, comprehensive private health insurance for you and your family with NO excess, critical illness, and life assurance.
Enhanced Leave: Enhanced paid family leave to support all new parents.

Work Environment & Culture

Flexible Working: Hybrid Working (e.g., From our London, Oxford Office)
Truly Inclusive Time Off: Our 'Bank Your Bank Holiday' program allows you to exchange public holidays for dates that hold personal or cultural significance to you.
Vibrant Social Culture: From regular Town Halls and team picnics to organised sports events, our social committee ensures frequent opportunities to connect and celebrate.
Green Commute: Cycle-to-Work scheme and convenient office locations near major transport hubs.

Ready to Build the Future?

If this opportunity excites you, apply now!

We are dedicated to creating a diverse environment and are proud to be an equal-opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

Genomics politely requests no contact from recruitment agencies. We do not accept speculative CVs from recruitment agencies nor accept the fees associated with them.

Apply Now

Refine Your Search

lead site reliability engineer jobs in thame, oxf

Staff Site Reliability Engineer

Manufacturing Engineer

Engineering Team Leader

Lead Chemical Engineer (Gasoline)

Continuous Improvement Engineer

Principal Systems Engineer (Group Lead)

Shift Engineer - Data Centres

Lead Electrical and Controls Engineer

Senior Process Project Engineer - Helium Recovery Infrastructure

Garage Technicians & Jnr Garage Technicians (Event Support Crew)

Systems Engineer

Field Service Engineer

Health and Safety Lead - Seat Test

Production Engineer - Optical & Semiconductor Systems

Head of Engineering - Quality

Unified Comms Manager

Shift Engineer - Data Centres

Electronics Design Lead (Multiple Locations)

Senior Automation Engineer, Laboratory Automation & Biobanking

Digital & IT Senior Analyst - Messaging