We are excited to offer this opportunity for a Translational Research Technician to join the RISE (Reducing Immune Stress from Excess cytokine release in advanced therapies) programme Medical Research Council (MRC) - funded research consortium focused on generating the evidence, tools and translational science needed to optimise, predict and mitigate toxicity from advanced cell and immunotherapies in cancer.
The post holder will be responsible for coordinating the day-to-day processing of clinical samples, including but not limited to blood and stool samples, collected from patients receiving CAR-T therapy or other immunotherapies as part of a prospective observational study. They will support a cross-institution research team to collect, log and process clinical samples for further downstream analysis.
This role is offered at a 1.0FTE fixed term for 4 years. On-site presence is expected for sample processing, key meetings, and consortium activities, given the collaborative and laboratory-facing nature of the role. Flexible hybrid working arrangements can be discussed where appropriate.
About RISE
RISE is led by Dr Jonathan Lim, Clinical Senior Lecturer and Honorary Consultant Medical
Oncologist at The University of Manchester and The Christie NHS Foundation Trust, and brings
together academic and clinical partners across Manchester alongside four industry partners.
RISE is an MRC-funded national Prosperity Partnership bringing together academia, NHS and industry partners to address a critical unmet need in advanced immune and cell therapies. These advanced therapies including CAR-T, TCR-T and TIL therapies have transformed cancer outcomes, however their wider adoption is limited by serious acute and chronic toxicities, particularly cytokine release syndrome (CRS) and neurotoxicity. Current management strategies remain reactive rather than preventative, and long-term pharmacovigilance frameworks are poorly defined.
RISE integrates mechanistic discovery science, clinical translational research and scalable technology platforms to identify and validate biomarkers and develop predictive and preventative strategies for safer implementation of advanced therapies. The programme comprises a prospective observational study of patients receiving standard-of-care CAR-T therapy and a parallel Phase 2 clinical trial evaluating a novel CRS-mitigation strategy. Longitudinal multimodal data will be generated across immune profiling, multi-omics, wearable monitoring and patient- reported outcomes, supported by artificial intelligence/machine learning modelling. The University of Manchester is the lead institution for RISE, working in partnership with academic groups within the Manchester ecosystem, The Christie NHS Foundation Trust and four industry partners.
What will you get in return:
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Fantastic market leading Pension scheme
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Excellent employee health and wellbeing services including an Employee Assistance Programme
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Exceptional starting annual leave entitlement, plus bank holidays
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Additional paid closure over the Christmas period
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Local and national discounts at a range of major retailers
As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Our University is positive about flexible working you can find out more here
Hybrid working arrangements may be considered.
Please be aware that due to the number of applications we are unfortunately not able to provide individual feedback on your application.
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Any recruitment enquiries from recruitment agencies should be directed to [email protected]
Any CV’s submitted by a recruitment agency will be considered a gift.
Enquiries about the vacancy, shortlisting and interviews:
Name: Holly Buendia, RISE Programme Manager
Email: [email protected]
General enquiries:
Email: [email protected]
Technical support:
https://jobseekersupport.jobtrain.co.uk/support/home
This vacancy will close for applications at midnight on the closing date.
Please see the link below for the Further Particulars document which contains the person specification criteria.
