Scientist i – lc ms/ms Work, Jobs in Glossop, Dby (with Salaries)

Principal Scientist I – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Scientist - Analytical Chemistry and Biological Monitoring (Band 5/EO)
Health and Safety Executive —Buxton
- £31,657 - £34,570 a year
- Part-time
- Data analysis skills
- Laboratory experience
- Analysis skills
12d
Senior Scientist I - LCMS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- English
- Master's degree
- Travel
Quick apply
Senior Scientist II – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Laboratory Engineer
Synexa Life Sciences —Macclesfield
- Full-time
- Engineering
- Laboratory experience
- Maintenance
Quick apply
Research Associate in Mass Spectrometry
The University of Manchester —Manchester
- £37,694 - £46,049 a year
- Hybrid work
- Doctoral degree
- Data analysis skills
- Annual leave

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scientist i – lc ms/ms jobs near glossop, dby

Principal Scientist I – LC-MS/MS

Synexa Life Sciences
Macclesfield

Quick apply

Job details

Full-time

Qualifications

Doctoral degree
Master's degree
HRIS
FDA regulations

Full job description

Role Overview

We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

Provide scientific leadership and SME support across LC-MS/MS studies
Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
Advise on method development, optimisation, and validation strategies
Support study teams in resolving technical issues and ensuring consistent assay performance
Contribute to client interactions, including scientific discussions, data interpretation, and method justification
Support proposals, bid defences, and scientific strategy discussions
Mentor and support development of laboratory scientists

Technical Expertise

Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

Peptides and proteins
Oligonucleotides
Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

Extensive experience working under GLP and GCP
Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
Experience supporting audits and regulatory inspections
Proven ability to lead scientific discussions with clients and defend analytical approaches and data
Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

PhD in Analytical Chemistry or related field, or MSc with significant industry experience
10 to 15 or more years of LC-MS/MS bioanalysis experience
Demonstrated expertise in method development, validation, and advanced troubleshooting

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scientist i – lc ms/ms jobs in glossop, dby

Principal Scientist I – LC-MS/MS

Scientist - Analytical Chemistry and Biological Monitoring (Band 5/EO)

Senior Scientist I - LCMS/MS

Senior Scientist II – LC-MS/MS

Laboratory Engineer

Research Associate in Mass Spectrometry

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