Principal scientist Work, Jobs in Knutsford, Chs (with Salaries)

Principal Scientist I – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Principal Clinical Scientist
Manchester University NHS Foundation Trust —Manchester
- £57,528 - £64,750 a year
- Full-time
- University
- AI
1d
Senior Scientist I - LCMS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- English
- Master's degree
- Travel
Quick apply
Senior Scientist II – Immunoassay Bioanalysis
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Scientific Director (LCMS)
Intertek —Manchester
- Doctoral degree
- Laboratory experience
- Master's degree
Quick apply
Senior Scientist II – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Principal Scientist / Associate Scientific Director – Computational Chemistry
Concept Life Sciences —Chapel en le Frith
- Full-time
- Hybrid work
- Doctoral degree
- Leadership
- Free parking
Principal Ecologist - BNG Specialist
AECOM —Manchester
- Full-time
- Hybrid work
Principal Consultant - Water Quality
APEM —Stockport
- Remote
- IT
- Leadership
- Communication skills
7d
Principal Data Scientist and Machine Learning Researcher (eDV)
Frontier Resourcing —Manchester
- Full-time
- Hybrid work
- Azure
- Doctoral degree
- Master's degree
Quick apply
21h
Principal Water Quality Scientist/ Modeller
AECOM —Manchester
- Full-time
- Hybrid work
- Master's degree
- Project management
- Scripting
Principal Consultant - Freshwater Fisheries
APEM —Stockport
- Remote
- Mentoring
- Communication skills
1d
Freshwater Fisheries Consultant
APEM —Stockport
- Remote
2d
Principal Hydrologist
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Data analysis skills
- Master's degree
Senior/Principal Hydrogeologist
AECOM —Manchester
- Full-time
- Hybrid work
- Master's degree
- Bachelor's degree

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Principal Clinical Scientist
Manchester University NHS Foundation Trust —Manchester
You will be responsible for managing a team of HCPC registered Clinical Scientists to deliver and develop the diagnostic workload and to develop the workforce.
£57,528 - £64,750 a year
1d
Principal Clinical Scientist
Sheffield Teaching Hospitals NHS Foundation Trust —Sheffield
The aim of the Network is to deliver a Pathology Service that provides all SYB patients and clinicians with equitable access to high-quality, innovative…
£55,690 - £62,682 a year
10d

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principal scientist jobs near knutsford, chs

Principal Scientist I – LC-MS/MS

Synexa Life Sciences
Macclesfield

Quick apply

Job details

Full-time

Qualifications

Doctoral degree
Master's degree
HRIS
FDA regulations

Full job description

Role Overview

We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

Provide scientific leadership and SME support across LC-MS/MS studies
Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
Advise on method development, optimisation, and validation strategies
Support study teams in resolving technical issues and ensuring consistent assay performance
Contribute to client interactions, including scientific discussions, data interpretation, and method justification
Support proposals, bid defences, and scientific strategy discussions
Mentor and support development of laboratory scientists

Technical Expertise

Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

Peptides and proteins
Oligonucleotides
Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

Extensive experience working under GLP and GCP
Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
Experience supporting audits and regulatory inspections
Proven ability to lead scientific discussions with clients and defend analytical approaches and data
Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

PhD in Analytical Chemistry or related field, or MSc with significant industry experience
10 to 15 or more years of LC-MS/MS bioanalysis experience
Demonstrated expertise in method development, validation, and advanced troubleshooting

Quick apply

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principal scientist jobs in knutsford, chs

Principal Scientist I – LC-MS/MS

Principal Clinical Scientist

Senior Scientist I - LCMS/MS

Senior Scientist II – Immunoassay Bioanalysis

Scientific Director (LCMS)

Senior Scientist II – LC-MS/MS

Principal Scientist / Associate Scientific Director – Computational Chemistry

Principal Ecologist - BNG Specialist

Principal Consultant - Water Quality

Principal Data Scientist and Machine Learning Researcher (eDV)

Principal Water Quality Scientist/ Modeller

Principal Consultant - Freshwater Fisheries

Freshwater Fisheries Consultant

Principal Hydrologist

Senior/Principal Hydrogeologist

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