Senior compliance assurance manager Work, Jobs in London, Eng (with Salaries)

Senior Manager, PV Operations
Orchard Therapeutics —London
- Full-time
- Hybrid work
- Writing skills
- Microsoft Office
- Bachelor's degree
Quick apply
Group & FinCrime Compliance Monitoring & Testing Senior Manager
Wise —London
- £89,000 - £127,000 a year
- Full-time
- Hybrid work
- Bachelor's degree
- Travel
- Organisational skills
Quick apply
Senior Manager - Records Management
Metropolitan Police —London
- £62,310 a year
- Full-time
- Hybrid work
- English
- Continuous improvement
- In-person
- Annual leave
- Work from home
Senior Area Facilities Manager
Fora Space Limited —London
- Full-time
- Communication skills
- Annual leave
- Flexible schedule
Quick apply
Senior Compliance Manager - Compliance Monitoring
Quilter —London
- Full-time
- Mentoring
Group & FinCrime Compliance Monitoring & Testing Senior Manager
Wise Australia Investments —London
- £89,000 - £127,000 a year
- Hybrid work
- Bachelor's degree
- Travel
- Organisational skills
Quality Assurance Officer
Health Now Ltd —London
- £38,000 - £50,000 a year
- Full-time
- Hybrid work
- Administrative experience
- Continuous improvement
- No degree
- Work from home
- Employee discount
Quick apply
1d
Compliance Manager
Quilter —London
- Full-time
- Organisational skills
- Communication skills
Group Quality and Compliance Manager
Kimbolton Lodge Ltd —Uxbridge
- £50,000 - £60,000 a year
- Full-time
- Hybrid work
- Continuous improvement
- Travel
- Training & development
Quick apply
3d
Technical Asset and Compliance Manager (Facilities Management)
OCS Group —London
- Up to £55,000 a year
- Monday to Friday
- Remote
- Analysis skills
- Communication skills
Quick apply
Compliance Manager
Creditspring —London
- Hybrid work
- Communication skills
Senior Manager Internal Audit
DS Smith —London
- Full-time
- Hybrid work
- Travel
- Communication skills
- Employee assistance programme
- Employee discount
16h
Senior Project Manager
Sagacity —London
- Full-time
- Hybrid work
- Continuous improvement
- Quality control
- Mentoring
Quick apply
Senior Manager, Compliance Advisory, Europe
Scotiabank —London
- Analysis skills
- No degree
- Communication skills
Senior Manager, Internal Audit
CFA Institute —London
- £80,000 - £90,000 a year
- Full-time
- AI
- Annual leave
Senior Cost Manager- Central PMO
Sizewell C —London
- £80,000 - £95,000 a year
- Part-time
- Analysis skills
- Continuous improvement
- Travel
- Annual leave
NDAO - Senior Records Manager
Police Digital Service —London
- £65,000 a year
- Travel
12d
Manager Financial Crime Compliance (Non-Transactional)
UK Export Finance —London
- £63,500 - £78,971 a year
- Full-time
- Analysis skills
- Presentation skills
- Training & development
2d
Workday Certified Senior Project Manager (HCM & Payroll)_UK Remote (Lead I - Enterprise Solutions)
UST —London
- Remote
- PMP
- Business development
- Mentoring
Quick apply
Senior Cost Manager- Central PMO
Mactech Energy Group —Westminster
- £80,000 - £90,000 a year
- Analysis skills
- Continuous improvement
- Travel
- Annual leave

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Senior Manager, PV Operations

Orchard Therapeutics -
London

Quick apply

Job details

Full-time

Qualifications

Clinical research
Writing skills
Regulatory reporting
Internal department liaison
Microsoft Office Suite
Microsoft Office
Database administration
Bachelor's degree
Continuous improvement
Continuous improvement cycles oversight
Risk management
Operational strategy development
Leadership
Communication skills
Internal quality assurance
Corporate regulatory compliance oversight
FDA regulations
Time management

Full job description

Reporting to: VP Pharmacovigilance

Location: London, UK / Hybrid

Orchard Therapeutics is a global biotechnology gene therapy company dedicated to transforming the lives of people affected by rare diseases through the development of innovative, potentially curative cell and gene therapies. Orchard has its global headquarters in London and is a wholly owned subsidiary of Kyowa Kirin, a Japan-based Global Specialty Pharmaceutical Company.

Job Summary

The Senior Manager, PV Operations is a key operational leader responsible for the execution and management of global pharmacovigilance operations. This role on a day to day basis ensures the seamless delivery of case management, regulatory reporting, and operational compliance across clinical and post-marketing portfolios.

This role serves as the primary operational interface for PV vendors and cross‑functional study teams. The Senior Manager, PV Operations is an emerging expert who translates the functional strategy into actionable operational plans, manages complex technical issues with limited guidance, and ensures that the "hands‑on" elements of the PV system are robust, scalable, and inspection‑ready.

Key Elements and Responsibilities

Lead and continuously improve global safety operations processes, including case intake, processing, and submissions, ensuring alignment with global PV regulations and company policies with close oversight of the pharmacovigilance vendors.
Oversee timely and compliant case processing and regulatory reporting of Individual Case Safety Reports (ICSRs) from all sources. Act as database business administrator for the Orchard safety database (Veeva Safety).
Ensure robust operational oversight of internal and external safety case management, including performance monitoring and quality metrics.
Provide strategic leadership for the selection, configuration, validation, and life-cycle management of safety systems and tools, in partnership with IT and Vendor Safety Systems teams.
Lead the design, implementation, and maintenance of standard operating procedures (SOPs), work instructions, and training for safety operations.
Act as key technical SME supporting inspection readiness and support internal audits, Health Authority inspections, and partner audits related to PV operations, coordinating responses and remediation plans.
Liaise with Orchard Quality Assurance colleagues to ensure audit programme of internal and external components of the pharmacovigilance system and partners run smoothly
Collaborate with safety physician, safety scientist and cross-functional teams to ensure efficient processes and systems for production of high-quality data for signal detection, aggregate safety reporting, benefit–risk assessments, and Risk Management Plans (RMPs).
Provide senior operational input into Safety Management Teams and cross-functional project teams, managing operational feasibility, timelines, and compliance risks.
Lead operational aspects of safety data exchange agreements (SDEAs) with partners and licensees and oversee literature surveillance workflows.

Requirements

Education, Experience & Knowledge

Education

Bachelor's degree or equivalent in a life science, pharmacy, nursing, or a related health field.
Relevant certifications in pharmacovigilance or drug safety are highly desirable.

Experience

Extensive experience in pharmacovigilance operations, with significant leadership in global ICSR management and regulatory reporting.
Experience with safety databases (Veeva Safety preferred but not required)
In-depth knowledge of global PV regulations (GVP, ICH, FDA, MHRA, EMA) and proven ability to implement them operationally.
Strong experience with safety databases and PV systems, including configuration, validation, and maintenance.
Demonstrated ability to lead and oversee PV vendors/CROs.
Experience with clinical studies, postmarketing safety, risk management plans and aggregate report preparation.

Desirable

Advanced degree in a relevant scientific or health-related field.
Experience with safety data exchange agreements (SDEAs) and literature surveillance.
Demonstrated ability to drive continuous improvement, process optimization, and automation in PV operations.
Demonstrated understanding of clinical development processes.
Experience with global product launches and implementation/assessment of complex risk minimisation measures.
Evidence of scientific contributions to the field (e.g., peer reviewed publications, invited presentations, guideline development, or recognised subject matter expertise in biologic safety).

Skills & Abilities

Self-motivated, with initiative and ability to take ownership of, and follow through with, specific tasks
Working knowledge of available information sources and ability to navigate multiple channels to secure required information
Works effectively with cross-functional teams to address complex issues and recommend actions with potentially significance impact
Effective time management and organization skills
Ability to multi-task and shift priorities quickly while working under tight deadlines
Excellent verbal and written communication skills
Strong PC experience and demonstrated proficiency in MS Office (Outlook, Word, Excel and Powerpoint)

Quick apply

Refine Your Search

senior compliance assurance manager jobs in london, eng

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