Principal data scientist Work, Jobs in Macclesfield, Chs (with Salaries)

Principal Scientist I – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Senior Scientist II – LC-MS/MS
Synexa Life Sciences —Macclesfield
- Full-time
- Doctoral degree
- Master's degree
Quick apply
Principal Scientist / Associate Scientific Director – Computational Chemistry
Concept Life Sciences —Chapel en le Frith
- Full-time
- Hybrid work
- Doctoral degree
- Leadership
- Free parking
Senior Data Scientist
Informed Solutions —Altrincham
- Hybrid work
- Azure
- Doctoral degree
- Master's degree
- Gym membership
- Referral programme
Quick apply
Principal Consultant - Water Quality
APEM —Stockport
- Remote
- IT
- Leadership
- Communication skills
7d
Principal Ecologist - BNG Specialist
AECOM —Manchester
- Full-time
- Hybrid work
Wildcard - Apply Now!
ONYX Insight —Manchester
- Full-time
Quick apply
Senior Data Scientist and Machine Learning Researcher (eDV)
Frontier Resourcing —Manchester
- Full-time
- Hybrid work
- Azure
- Doctoral degree
- Master's degree
Quick apply
15h
Principal Architect
AECOM —Manchester
- Full-time
- Hybrid work
- AutoCAD
- Microsoft Office
- Communication skills
6d
Principal Market Development Specialist
Waters Corporation —Wilmslow
- Hybrid work
- Sales
- Business development
- Bachelor's degree
Principal Nuclear Project Planner
AECOM —Warrington
- Full-time
- Hybrid work
- Analysis skills
- Communication skills
Freshwater Fisheries Consultant
APEM —Stockport
- Remote
2d
Advisory Senior Consultant
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Analysis skills
- Continuous improvement
13d
Principal EC&I Engineer (Nuclear)
AECOM —Warrington
- Full-time
- Hybrid work
- Engineering
- Project management
- Leadership
Principal Hydrologist
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Data analysis skills
- Master's degree
Data Architect
PA Consulting —Manchester
- Full-time
- Hybrid work
- Azure
- Mentoring
- AI
- Annual leave
Quick apply
Senior/Principal Hydrogeologist
AECOM —Manchester
- Full-time
- Hybrid work
- Master's degree
- Bachelor's degree
Principal Dams & Reservoir Engineer
AtkinsRéalis —Manchester
- Full-time
- Hybrid work
- Construction
- Communication skills
Principal Civil Engineer
AECOM —Manchester
- Full-time
- Hybrid work
- Engineering
- Leadership
Lead Machine Learning Engineer (Manchester)
Fitch Group —Manchester
- Azure
- Java
- Master's degree

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principal data scientist jobs near macclesfield, chs

Principal Scientist I – LC-MS/MS

Synexa Life Sciences
Macclesfield

Quick apply

Job details

Full-time

Qualifications

Doctoral degree
Master's degree
HRIS
FDA regulations

Full job description

Role Overview

We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

Provide scientific leadership and SME support across LC-MS/MS studies
Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
Advise on method development, optimisation, and validation strategies
Support study teams in resolving technical issues and ensuring consistent assay performance
Contribute to client interactions, including scientific discussions, data interpretation, and method justification
Support proposals, bid defences, and scientific strategy discussions
Mentor and support development of laboratory scientists

Technical Expertise

Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

Peptides and proteins
Oligonucleotides
Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

Extensive experience working under GLP and GCP
Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
Experience supporting audits and regulatory inspections
Proven ability to lead scientific discussions with clients and defend analytical approaches and data
Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

PhD in Analytical Chemistry or related field, or MSc with significant industry experience
10 to 15 or more years of LC-MS/MS bioanalysis experience
Demonstrated expertise in method development, validation, and advanced troubleshooting

Quick apply

Refine Your Search

principal data scientist jobs in macclesfield, chs

Principal Scientist I – LC-MS/MS

Senior Scientist II – LC-MS/MS

Principal Scientist / Associate Scientific Director – Computational Chemistry

Senior Data Scientist

Principal Consultant - Water Quality

Principal Ecologist - BNG Specialist

Wildcard - Apply Now!

Senior Data Scientist and Machine Learning Researcher (eDV)

Principal Architect

Principal Market Development Specialist

Principal Nuclear Project Planner

Freshwater Fisheries Consultant

Advisory Senior Consultant

Principal EC&I Engineer (Nuclear)

Principal Hydrologist

Data Architect

Senior/Principal Hydrogeologist

Principal Dams & Reservoir Engineer

Principal Civil Engineer

Lead Machine Learning Engineer (Manchester)

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