We are looking for a motivated team member to join Phytoform’s R&D efforts in the development of a plant artificial chromosome, a cutting-edge project funded by the Advanced Research and Invention Agency (ARIA), delivered in close collaboration with academic partners, including the University of Cambridge, the University of Western Australia and the Australian Genome Foundry at Macquarie University. You’ll be part of a consortium developing a synthetic chromosome for plants with particular focus on potato and moss (Physcomitrium patens). The objective for this role is to develop detection and characterisation methods using molecular and cytogenetic techniques. This is an opportunity suitable for an enthusiastic synthetic or molecular biologist, who is keen to develop a completely novel genetic engineering system. Previous knowledge of plants is not a requirement, but it is highly beneficial. If you have previously been part of an academic or industry team but now would like to work in a fast-paced start-up environment and develop a project from the ground up then you would be a great fit.
What You’ll Do
- Design and execute experiments to advance plant genome engineering technologies.
- Establish novel methods for detecting and distinguishing nuclear genetic material (e.g. cytology, live-cell imaging, or in vitro alternatives).
- Develop and optimise delivery systems for introducing genetic material into plant cells (e.g. protoplast fusion, PEG-mediated transformation).
- Contribute to an innovative R&D programme with high scientific autonomy and opportunity for professional development.
Role Requirements
- PhD in synthetic, cellular, or molecular biology, or related field. MSc with 3+ years of relevant research experience can also be considered.
- Proven ability to solve complex problems in cell and molecular biology with rapid iteration.
- Demonstrated experience designing, executing, and troubleshooting experimental protocols independently.
- Clear evidence of experience in fluorescence imaging and analysis.
- Ability to deliver high-quality results within defined project timelines. Thrive in a fast-paced environment with evolving priorities.
- Clear and effective scientific communication (written and verbal).
- Meticulous experimental documentation and record keeping.
- Enthusiasm for learning and applying new techniques.
Beneficial Experience
- Working with multiple species, ideally moss (Physcomitrium patens), potato or tomato.
- Automated image analysis using tools such as ImageJ macros and CellProfiler workflows.
- Live-cell CRISPR-based imaging approaches (e.g. dCas9, dCas13, SunTag), alongside other nuclear detection methods such as immunostaining, FISH, and GISH
- Plasmid design software (geneious, benchling, snapgene) and molecular cloning methods (gateway, goldengate, gibson).
- Hands on experience working with plant tissue culture, ideally protoplast systems.
- Protoplast transformation PEG-mediated using plasmids and other protoplast genetic manipulation methods such as cell fusion.
- Use of an electronic lab notebook software for record keeping, shared cloud space, and time-management tools.
If you’re looking for a new challenge and enjoy working as part of a small, multidisciplinary team where new ideas are welcomed, then we would love to meet you! And if your experience does not align perfectly with every qualification listed, but you are excited by the project and believe you could contribute strongly, we still encourage you to apply.
Your application should consist of a single PDF containing your CV and a cover letter. In your cover letter, please include the description of a technology, method, workflow, or system that you personally developed, implemented, or significantly improved in a previous role. We are particularly interested in understanding the problem you were solving and your specific contribution.
Location: Harpenden, Greater London commuter area, United KingdomContract: Full-time, 2-year fixed-term (renewable based on milestones and funding)Visa: Please note that this role is not eligible for visa sponsorship. Applicants must have the right to work in the UK.
Start Date: As soon as possible
This job is part of an Advanced Research + Invention Agency funded project.
Please apply on our website or send your application to [email protected] with “Research Scientist Q2-2026” in the subject line.
Pay: £41,000.00-£43,400.00 per year
Benefits:
- Cycle to work scheme
- Free parking
- On-site parking
- Private medical insurance
Ability to commute/relocate:
- Harpenden AL5 2JQ: reliably commute or plan to relocate before starting work (required)
Education:
Work authorisation:
- United Kingdom (required)
Work Location: In person
