Senior research engineer Work, Jobs in Wraxall, Som (with Salaries)

Research Associate/Senior Research Associate in Intracellular Transport and Protein Design
University of Bristol —Clifton
- £44,746 - £50,253 a year
- Full-time
- Doctoral degree
- Research
- University
12d
Senior Town Planner
AECOM —Bristol
- Full-time
- Hybrid work
- Writing skills
Machine Learning Engineer (Mid to Principal)
Rowden —Bristol
- £50,000 - £95,000 a year
- Full-time
- Hybrid work
- Doctoral degree
- No degree
- Mentoring
Quick apply
Senior Teaching Technician: Geotechnical Engineering
University of the West of England —Frenchay
- £34,610 - £38,784 a year
- Full-time
- University
- Mentoring
- School
- Annual leave
3d
Senior Software Engineer, Windows/Desktop Applications - Bristol, United Kingdom
Speechify —Bristol
- Remote
- Software troubleshooting
- Windows
- C++
9d
Digital Delivery Manager
Office for National Statistics —Newport
- £41,985 - £47,121 a year
- Part-time
- Hybrid work
- Presentation skills
- Agile
- Leadership
3d
Structures Inspector
BES Group —Bristol
- £40,000 a year
- Full-time
- Civil engineering
- Travel
- Annual leave
- Employee assistance programme
12d
Operations Manager
Dalkia —Bridgwater
- Engineering
- Research
- Team management
Senior Linux Distribution & Validation Engineer
Graphcore —Bristol
- £73,500 - £131,700 a year
- Scripting
- Linux
Principal Board Test Engineer
Graphcore —Bristol
11d
Consultant, UX Designer - Tech Consultancy - Defence and Security
Deloitte —Bristol
- Hybrid work
Sr. Consultant
ioMosaic Corporation —Bath
- Full-time
- Engineering
- Bachelor's degree
- Travel
Quick apply
Principal Engineer (Cloud) - AWS
QinetiQ —Bristol
- £76,500 - £85,000 a year
- Full-time
- AWS
- Employee discount
Mechanical Engineer
Public Sector Resourcing —Bristol
- Full-time
- Engineering
- Master's degree
- Communication skills
Copy of Head of Structural Engineering – UK & Ireland
AECOM —Bristol
- Full-time
- Hybrid work
- Business development
- Leadership
- Communication skills
Senior Machine Learning Engineer (Large Systems)
Graphcore —Bristol
- Doctoral degree
- Master's degree
- Software development
- Annual leave
- Employee assistance programme
Senior Integrated Management System Engineer
Graphcore —Bristol
Senior Product Engineer
Cytiva —Cardiff
- Full-time
- Engineering
- Continuous improvement
- No degree
- Annual leave
PVD Senior Process Engineer (E)
KLA —Newport
- Weekend availability
- Doctoral degree
- Data analysis skills
- Master's degree
- Annual leave
Senior / Principal Game Engineer
Rocket Science Group —Cardiff
- Full-time
- Hybrid work
- Analysis skills
- Mentoring
- Leadership
- Annual leave
- Work from home

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Research Associate/Senior Research Associate in Intracellular Transport and Protein Design

University of Bristol -
Clifton

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Job details

Full-time
£44,746 - £50,253 a year
12 days ago

Qualifications

Doctoral degree
Research
Multidisciplinary collaboration
Molecular biology

Full job description

The role

A post-doctoral position is available to investigate and engineer the molecular mechanisms that regulate intracellular transport by cytoskeletal motor proteins. This Wellcome-funded post is available for 3 years within the laboratory of Dr Jessica Cross in the School of Chemistry at the University of Bristol. The successful candidate will work closely with collaborators including Professor Dek Woolfson (protein design), Dr Mark Dodding (molecular cell biology), Dr Andrew Carter (structural biology) and Dr Simon Bullock (cell biology). The project will combine computational protein design, protein expression and purification, structural and biophysical characterisation, and cell biology to understand how coiled-coil adaptor proteins regulate dynein and kinesin motors, and to engineer novel switchable proteins capable of controlling intracellular transport.

What will you be doing?

Specifically, the work will investigate how the dynein adaptor Bicaudal D2 (BicD2) regulates intracellular transport through dynamic coiled-coil conformational changes. Building on our discoveries of conformational regulation and peptide-mediated control of kinesin-1 (Cross et al. Cell Chemical Biology, 2021; Weijman et al. Science Advances, 2022; Rhys, Cross, Dawson et al. Nature Chemical Biology, 2022, Cross et al. Nature Chemical Biology, 2024; Shulka, Cross, Kish et al. eLife, 2025), the appointee will engineer novel protein and peptide switches to control BicD2 activity using a combination of computational protein design, protein biochemistry and cell biology. We anticipate that this work will provide fundamental mechanistic insights into motor regulation while delivering new tools to manipulate intracellular transport and inform future therapeutic strategies for diseases associated with motor dysfunction.

You should apply if

This position would suit a talented and ambitious early-career researcher with an interest in protein engineering, structural biology, biophysics or cell biology. Essential skills include experience in recombinant protein expression and purification, molecular biology and protein characterisation, together with the ability to design and conduct independent research. Experience in computational protein design, structural biology, cell biology, motor proteins or intracellular transport would be advantageous, but is not essential, and we particularly encourage applicants who are enthusiastic about developing expertise across disciplines.

The successful applicant will join a highly collaborative research environment and work closely with Professor Dek Woolfson, Dr Mark Dodding, Dr Andrew Carter and Dr Simon Bullock. There will be excellent opportunities for training in computational protein design, advanced biophysical techniques, single-molecule assays and live-cell imaging. The appointee will be expected to work seamlessly across collaborating laboratories to maximise opportunities for interdisciplinary research.

Additional information

To find out more about what it's like to work in the Faculty of Engineering, and how the Faculty supports people to achieve their potential, please see our staff blog:

https://engineering.blogs.bristol.ac.uk/category/engineering-includes-me/

Contract type: Open ended with fixed funding until 04/01/2030 (36 months funding)

Work pattern: Full time/35 hours per week

Grade: Grade I / J Pathway 2

Salary: Grade I £39,906 – £44,746 or Grade J £44,746 - £50,253 depending on expereince per annum

School/Unit: Schools of Engineering Mathematics and Technology and Chemistry

This advert will close at 23:59 UK time on 21/09/26

For informal queries please contact: Jessica Cross, Lecturer Email: [email protected]

Our strategy and mission

We recently launched our strategy to 2030 tying together our mission, vision and values.

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Refine Your Search

senior research engineer jobs in wraxall, som

Research Associate/Senior Research Associate in Intracellular Transport and Protein Design

Senior Town Planner

Machine Learning Engineer (Mid to Principal)

Senior Teaching Technician: Geotechnical Engineering

Senior Software Engineer, Windows/Desktop Applications - Bristol, United Kingdom

Digital Delivery Manager

Structures Inspector

Operations Manager

Senior Linux Distribution & Validation Engineer

Principal Board Test Engineer

Consultant, UX Designer - Tech Consultancy - Defence and Security

Sr. Consultant

Principal Engineer (Cloud) - AWS

Mechanical Engineer

Copy of Head of Structural Engineering – UK & Ireland

Senior Machine Learning Engineer (Large Systems)

Senior Integrated Management System Engineer

Senior Product Engineer

PVD Senior Process Engineer (E)

Senior / Principal Game Engineer

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