Overview
The School of Mathematical and Physical Sciences is seeking to appoint a Research Associate to work on a project funded as part of a BBSRC grant under the guidance of Professor Nick Turner at the University of Sheffield exploring the development of microscopy assays for recognition of extracellular vesicles.
You will form part of a growing team looking at pushing the capabilities of molecular imprinting techniques and targeted recognition polymers at the biological interface. Molecularly Imprinted Polymers (MIPs) are simple, elegant biomimetics that incorporate binding sites bearing steric and chemical functionality complementary to a given target. They represent a generic, versatile, scalable, cost-effective approach to the creation of synthetic molecular receptors and have uses in separation sciences, purification, sensors and catalysis. This multi-disciplinary project will explore the capability of nanoscale MIPs to selectively recognise surface proteins on extracellular vesicles - biological entities that are secreted from cells and act as transporters, signallers and biomarkers. This project is in conjunction with MetaguideX, and OXford Nanoimaging, and will require engagement with the Central Laser Facility at Harwell.
You will be a highly motivated individual with a background in molecular imprinting, cell biology and microscopy. Expertise in a good range of common bioanalytical and protein handling techniques will be required; and prior experience of some of the following areas will be advantageous: confocal/electron microscopy, molecular modelling, surface chemistry and molecular imprinting.
You will hold a good first degree in biochemistry, chemistry, or similar; and hold, or about to examine for, a doctoral level qualification (PhD) in a related subject.
Main duties and responsibilities
You will work across the University's facilities and with collaborators via regular interaction with academic and industrial partners to ensure the progress of work adheres to the programme timescales. Report problems and non-compliances to the Project Team.
Work with external collaborators and represent the University and the Turner group at conferences.
Design, develop and synthesise molecularly imprinted polymer films and nanomaterials selective for specific surface protein targets.
Perform, using suitable analytical equipment, affinity and selectivity studies on developed MIPs towards optimisation of MIP/EV interactions.
Perform, using suitable microscopy equipment, binding studies of MIP/EV interactions.
Dissemination of the results of the research as the work progresses, in verbal and in written form, through attendance at regular project meetings, both internal and external.
Person Specification Our diverse community of staff and students recognises the unique abilities, backgrounds, and beliefs of all. We foster a culture where everyone feels they belong and are respected. Even if your past experience doesn't match perfectly with this role's criteria, your contribution is valuable, and we encourage you to apply. Please ensure that you reference the application criteria in the application statement when you apply.
Hold a good first degree (or equivalent experience), in biochemistry, pharmacology, pharmacy, chemistry, or similar
Have or about to obtain a doctoral level qualification (PhD) in a related subject.
Experience with a range of microscopy techniques
Experience with a range of bioanalytical techniques to analyse MIP performance
Experience of working with biological targets and samples (cells, EVs).
Experience of cell assays
Experience with molecular imprinting.
Experience with enzymatic assays.
Excellent problem solving and analytical skills, demonstrated logical and rigorous approach to work.
Demonstrated ability to work both as part of a team, and on own initiative.
Well-developed self-management skills with the ability to prioritize work appropriately, deal with several competing demands, manage own time effectively and deliver results to an agreed schedule.
Strong verbal and written communication in a team environment.
Ability to communicate effectively with colleagues from a wide range of scientific and lay backgrounds.
Good oral, visual, and written communication skills.
Further Information
Professor of Bioanalytical Chemistry
https://sheffield.ac.uk/mps
For informal enquiries about this job contact Professor Nick Turner: on [email protected]
Next steps in the recruitment process
It is anticipated that the selection process will take place at the end of June 2026. This will consist of an interview with a short presentation.. We plan to let candidates know if they have progressed to the selection stage within two weeks of the closing date. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact [email protected].
Our vision and strategic plan
We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision ().
What we offer
A minimum of 41 days annual leave including bank holiday and closure days (pro rata) with the ability to purchase more.
Flexible working opportunities, including hybrid working for some roles.
Generous pension scheme.
A wide range of discounts and rewards on shopping, eating out and travel.
A variety of staff networks, providing opportunities for social interaction, peer support and personal development (for example, Race Equality, LGBT+, Women’s and Parent’s networks).
Recognition Awards to reward staff who go above and beyond in their role.
A commitment to your development access to learning and mentoring schemes
A range of generous family-friendly policies
paid time off for parenting and caring emergencies
access to menopause support in the workplace
paid time off and support for fertility treatment
and more
We are a Disability Confident Leader (opens in a new window). If you have a disability and meet the essential criteria for this job you will be invited to take part in the next stage of the selection process.
Possession of a criminal record is not an automatic bar to employment at the University of Sheffield. We recognise the value of steady employment in the rehabilitation process and examine each case in its own right. More information can be found on our Information for candidates page:- sheffield.ac.uk/jobs/candidates (opens in a new window).
