Senior scientist Work, Jobs in Yarnton, Oxf (with Salaries)

Senior Scientist, Computational Chemistry
Vertex Pharmaceuticals —Oxford
- Full-time
- Doctoral degree
- Data analysis skills
- Scripting
7d
Senior Research Scientist I - Infectious Diseases
Immunocore —Oxford
- Full-time
- Doctoral degree
- Master's degree
- Presentation skills
Senior Research Scientist
University of Oxford —Oxford
- £49,119 - £58,265 a year
- Full-time
- Doctoral degree
- Computer Science
- Analysis skills
Senior Scientist
Genomics —Oxford
- Full-time
- Hybrid work
- Python
- Annual leave
Postdoctoral Research Scientist
University of Oxford —Oxford
- £39,424 - £47,779 a year
- Full-time
- Doctoral degree
23h
Principal Scientist, Inflammation Research
Gilead Sciences —Oxford
- Full-time
- Doctoral degree
- Communication skills
Research Assistant
University of Oxford —Oxford
- £35,681 - £41,636 a year
- Full-time
- Administrative experience
- Communication skills
- Annual leave
- Employee assistance programme
23h
Senior Research Scientist I, Engager Evaluation | 10 months FTC
Immunocore —Oxford
- Doctoral degree
- Master's degree
- Bachelor's degree
Research Grants Manager
University of Oxford —Oxford
- £39,424 - £51,983 a year
- Full-time
- Oracle
- Microsoft Office
- Contracts
Formulation Development Scientist
Immunocore —Oxford
- Doctoral degree
- Master's degree
- Bachelor's degree
(Fixed Term) Senior Research Associate, Clinical Biomarker Laboratory, Flow Cytometry
Moderna, Inc. —Oxford
- Full-time
- Laboratory experience
- Microsoft Office
- Presentation skills
- Annual leave
Oxford Cancer Operations Manager
University of Oxford —Oxford
- £39,424 - £47,779 a year
- Full-time
- Administrative experience
- Project management
- Communication skills
- Annual leave
14d
Senior Mammalian Upstream Process Development Scientist I | FTC 9 months
Immunocore —Oxford
- Doctoral degree
- Engineering
- Master's degree
Professorship of Dementia Research
University of Oxford —Oxford
Clinical Research Fellow in Translational Myeloma Research
University of Oxford —Oxford
- £38,831 - £52,656 a year
- Full-time
- Doctoral degree
- Bachelor's degree
- Annual leave
23h
Senior Core Transport and Turbulence Modeller
UK Atomic Energy Authority —Abingdon
- £57,117 a year
- Full-time
- Hybrid work
- Doctoral degree
- Communication skills
- Python
- Annual leave
- Employee assistance programme
Quick apply
Junior Product Development Scientist
pladis —High Wycombe
- Full-time
- Employee assistance programme
- Employee discount
Manager R&D Labs (CNAP)
Convatec —Abingdon
- Full-time
- Doctoral degree
- Engineering
- In-person
Senior Exhaust Physicist
UK Atomic Energy Authority —Culham
- £57,117 a year
- Full-time
- Doctoral degree
- Annual leave
- Employee assistance programme
12d
Global Scientific Lead - Clinical Outcome Assessment (COA) Strategy Consulting - Multiple locations - Hybrid/Home-based
IQVIA —Oxford
- Full-time
- Hybrid work
- Management
- Doctoral degree
- English
5d

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Senior Scientist, Computational Chemistry

Vertex Pharmaceuticals -
Oxford

Apply Now

Job details

Full-time
7 days ago

Qualifications

Doctoral degree
Data analysis skills
Scripting
AI
Communication skills
Python

Full job description

Job Description

We are seeking a highly motivated and experienced Senior Scientist in Computational Chemistry to join our Computational Drug Design group in Oxford. The successful candidate will play a central role in advancing drug discovery projects through the innovative application of molecular modelling and computational chemistry approaches.

As a key scientific contributor, you will generate and test design hypotheses, help shape project strategy, and work closely with scientists across multiple disciplines to guide the progression of novel compounds from hit identification through candidate nomination. You will be expected to provide clear and high-impact computational insight to guide project direction and decision-making.

In addition to project-facing work, you will contribute to the development of internal molecular modelling capabilities, workflows, and scientific strategy. Success in this role requires strong scientific judgement, excellent communication skills, and the ability to thrive in a highly collaborative, cross-functional environment while fostering a culture of scientific excellence and innovation.

Responsibilities:

Lead computational chemistry and molecular modelling efforts on active drug discovery projects to accelerate the identification and optimisation of drug candidates
Drive structure- and ligand-based molecular design using a range of computational techniques, including docking, molecular dynamics simulations, and free energy calculations
Generate mechanistic insight into protein–ligand interactions to support compound design and prioritisation
Apply AI/ML approaches, where appropriate, to support molecular design, compound prioritisation, and property optimisation
Make timely, data-driven decisions to maintain focus on key project objectives and deliver high-impact outcomes
Collaborate proactively with computational chemists, cheminformaticians, medicinal chemists, structural biologists, DMPK and safety scientists to develop strategy and drive project progression
Evaluate, implement, and communicate new methodologies, workflows, and best practices across teams
Contribute to the enhancement of internal R&D capabilities through cross-functional collaboration

Requirements:

Ph.D. (or equivalent) in Computational Chemistry, Chemistry, Biophysics, or a related discipline
Significant relevant experience in small-molecule drug discovery, with a strong track record of impact in structure-based drug design
Deep understanding of protein–ligand interactions and their application to compound design
Hands-on experience with commercial and open-source molecular modelling software, such as Schrödinger, MOE, OpenEye, and workflow/data analysis tools such as KNIME or Pipeline Pilot
Experience applying computational methods such as docking, molecular dynamics, and free energy calculations to support project decisions
Strong motivation, excellent interpersonal, communication, and presentation skills, with the ability to work effectively in cross-functional teams

Desirables:

Relevant postdoctoral and/or industry experience
Track record of impactful publications, patents, and/or contributions to discovery pipeline progression
Scripting or programming experience in Python or similar languages
Experience in advanced Molecular Dynamics simulation methods and/or QM methods in drug discovery
Experience in AI/ML applications for drug discovery, including generative models or ligand/protein co-folding approaches

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid : work remotely up to two days per week; or select
2. On-Site : work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]

Apply Now

Refine Your Search

senior scientist jobs in yarnton, oxf

Senior Scientist, Computational Chemistry

Senior Research Scientist I - Infectious Diseases

Senior Research Scientist

Senior Scientist

Postdoctoral Research Scientist

Principal Scientist, Inflammation Research

Research Assistant

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Senior Exhaust Physicist

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